SPECT Versus PET Myocardial Perfusion Imaging in Patients with Equivocal CT

被引:7
作者
Singh, Vasvi [1 ,2 ,3 ,4 ]
Di Carli, Marcelo F. [1 ,2 ,3 ,4 ,5 ]
机构
[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Cardiovasc Imaging Program, Boston, MA 02115 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Cardiovasc Imaging Program, Boston, MA 02115 USA
[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA 02115 USA
[4] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Cardiovasc Med, Boston, MA 02115 USA
[5] Brigham & Womens Hosp, 75 Francis St,ASB-L1 037C, Boston, MA 02115 USA
关键词
Myocardial perfusion imaging; Computed tomography; Myocardial blood flow; CORONARY-ARTERY-DISEASE; POSITRON-EMISSION-TOMOGRAPHY; FLOW RESERVE; COMPUTED-TOMOGRAPHY; VASCULAR DYSFUNCTION; DIAGNOSTIC-ACCURACY; PROGNOSTIC VALUE; RB-82; PET; ANGIOGRAPHY; RISK;
D O I
10.1007/s11886-020-01287-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of Review The most pertinent clinical question in post-coronary computed tomography angiography (CCTA) patients is the assessment of the physiological significance of an anatomically identified stenosis. The clinical application of radionuclide MPI using single-photon emission computed tomography (SPECT) versus positron emission tomography (PET) in the evaluation and management of patients with an inconclusive CCTA is reviewed using a case-based approach. Recent Findings Recent evidence suggests that CCTA is the most sensitive non-invasive test to exclude angiographic CAD and may be an effective first-line test especially among symptomatic low-intermediate risk patients. However, in the presence of angiographic atherosclerosis, its specificity and positive predictive value for identifying flow-limiting stenosis are modest. Radionuclide myocardial perfusion imaging offers accurate quantitative assessment of myocardial ischemia, which helps with risk stratification and patient management especially the potential need for revascularization. Routine accurate quantifications of myocardial blood flow and flow reserve are major advantages of PET MPI, which are especially useful when used in patients at intermediate-high clinical risk.
引用
收藏
页数:10
相关论文
共 42 条
[1]   Anatomic spectrum of left coronary artery anomalies and associated mechanisms of coronary insufficiency [J].
Angelini, Paolo ;
Uribe, Carlo .
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2018, 92 (02) :313-321
[2]   Anomalous origin of the coronary artery arising from the opposite sinus: prevalence and outcomes in patients undergoing coronary CTA [J].
Cheezum, Michael K. ;
Ghoshhajra, Brian ;
Bittencourt, Marcio S. ;
Hulten, Edward A. ;
Bhatt, Ami ;
Mousavi, Negareh ;
Shah, Nishant R. ;
Valente, Anne Marie ;
Rybicki, Frank J. ;
Steigner, Michael ;
Hainer, Jon ;
MacGillivray, Thomas ;
Hoffmann, Udo ;
Abbara, Suhny ;
Di Carli, Marcelo F. ;
Yeh, Doreen DeFaria ;
Landzberg, Michael ;
Liberthson, Richard ;
Blankstein, Ron .
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2017, 18 (02) :224-235
[3]   Comparison of Coronary CT Angiography, SPECT, PET, and Hybrid Imaging for Diagnosis of Ischemic Heart Disease Determined by Fractional Flow Reserve [J].
Danad, Ibrahim ;
Raijmakers, Pieter G. ;
Driessen, Roel S. ;
Leipsic, Jonathon ;
Raju, Rekha ;
Naoum, Chris ;
Knuuti, Juhani ;
Maki, Maija ;
Underwood, Richard S. ;
Min, James K. ;
Elmore, Kimberly ;
Stuijfzand, Wynand J. ;
van Royen, Niels ;
Tulevski, Igor I. ;
Somsen, Aernout G. ;
Huisman, Marc C. ;
van Lingen, Arthur A. ;
Heymans, Martijn W. ;
van de Ven, Peter M. ;
van Kuijk, Cornelis ;
Lammertsma, Adriaan A. ;
van Rossum, Albert C. ;
Knaapen, Paul .
JAMA CARDIOLOGY, 2017, 2 (10) :1100-1107
[4]   Quantitative Assessment of Myocardial Perfusion in the Detection of Significant Coronary Artery Disease Cutoff Values and Diagnostic Accuracy of Quantitative [15O]H2O PET Imaging [J].
Danad, Ibrahim ;
Uusitalo, Valtteri ;
Kero, Tanja ;
Saraste, Antti ;
Raijmakers, Pieter G. ;
Lammertsma, Adriaan A. ;
Heymans, Martijn W. ;
Kajander, Sami A. ;
Pietilae, Mikko ;
James, Stefan ;
Soerensen, Jens ;
Knaapen, Paul ;
Knuuti, Juhani .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (14) :1464-1475
[5]   Abnormal epicardial coronary resistance in patients with diffuse atherosclerosis but "normal" coronary angiography [J].
De Bruyne, B ;
Hersbach, F ;
Pijls, NHJ ;
Bartunek, J ;
Bech, JW ;
Heyndrickx, GR ;
Gould, KL ;
Wijns, W .
CIRCULATION, 2001, 104 (20) :2401-2406
[6]   Comparison of Coronary Computed Tomography Angiography, Fractional Flow Reserve, and Perfusion Imaging for Ischemia Diagnosis [J].
Driessen, Roel S. ;
Danad, Ibrahim ;
Stuijfzand, Wijnand J. ;
Raijmakers, Pieter G. ;
Schumacher, Stefan P. ;
van Diemen, Pepijn A. ;
Leipsic, Jonathon A. ;
Knuuti, Juhani ;
Underwood, S. Richard ;
van de Ven, Peter M. ;
van Rossum, Albert C. ;
Taylor, Charles A. ;
Knaapen, Paul .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (02) :161-173
[7]   Quantitative Assessment of Coronary Microvascular Function Dynamic Single-Photon Emission Computed Tomography, Positron Emission Tomography, Ultrasound, Computed Tomography, and Magnetic Resonance Imaging [J].
Feher, Attila ;
Sinusas, Albert J. .
CIRCULATION-CARDIOVASCULAR IMAGING, 2017, 10 (08)
[8]   Prediction of Short-Term Cardiovascular Events Using Quantification of Global Myocardial Flow Reserve in Patients Referred for Clinical 82Rb PET Perfusion Imaging [J].
Fukushima, Kenji ;
Javadi, Mehrbod S. ;
Higuchi, Takahiro ;
Lautamaeki, Riikka ;
Merrill, Jennifer ;
Nekolla, Stephan G. ;
Bengel, Frank M. .
JOURNAL OF NUCLEAR MEDICINE, 2011, 52 (05) :726-732
[9]   Appropriateness of percutaneous revascularization of coronary chronic total occlusions: an overview [J].
Galassi, Alfredo R. ;
Brilakis, Emmanouil S. ;
Boukhris, Marouane ;
Tomasello, Salvatore D. ;
Sianos, Georgios ;
Karmpaliotis, Dimitri ;
Di Mario, Carlo ;
Strauss, Bradley H. ;
Rinfret, Stephane ;
Yamane, Masahisa ;
Katoh, Osamu ;
Werner, Gerald S. ;
Reifart, Nicolaus .
EUROPEAN HEART JOURNAL, 2016, 37 (35) :2692-2700B
[10]   Frequency and clinical implications of fluid dynamically significant diffuse coronary artery disease manifest as graded, longitudinal, base-to-apex myocardial perfusion abnormalities by noninvasive positron emission tomography [J].
Gould, KL ;
Nakagawa, Y ;
Nakagawa, K ;
Sdringola, S ;
Hess, MJ ;
Haynie, M ;
Parker, N ;
Mullani, N ;
Kirkeeide, R .
CIRCULATION, 2000, 101 (16) :1931-1939