Synthesis of Ureidomuraymycidine Derivatives for Structure-Activity Relationship Studies of Muraymycins

被引：19

作者：

Aleiwi, Bilal A. ^{[1
]}

Schneider, Christopher M. ^{[1
]}

Kurosu, Michio ^{[1
]}

机构：

[1] Univ Tennessee, Hlth Sci Ctr, Coll Pharm, Dept Pharmaceut Sci, Memphis, TN 38163 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 08期

基金：

美国国家卫生研究院;

关键词：

PEPTIDOGLYCAN BIOSYNTHESIS INHIBITORS; GLUTAMIC-ACID-DERIVATIVES; ALPHA-AMINO-ACIDS; EFFICIENT; CAPREOMYCIDINE; TARGET; PSEUDOPEPTIDES; LACTONES; ANALOGS; ENZYME;

D O I：

10.1021/jo300205b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One of the key constituents of the muraymycins is the 6-membered cyclic guanidine, (2S,3S)-muraymycidine (or epi-capreomycidine). In order to diversify the structure of the oligopeptide moiety of the muraymycins for thorough structure activity relationship studies, we have developed a highly stereoselective synthesis of ureidomuraymycidine derivatives with the lactone 4a.

引用

页码：3859 / 3867

页数：9

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