Recommendations of the American Association of Physicists in Medicine on dosimetry, imaging, and quality assurance procedures for 90Y microsphere brachytherapy in the treatment of hepatic malignancies

被引：198

作者：

Dezarn, William A. ^{[1
]}

Cessna, Jeffery T. ^{[2
]}

DeWerd, Larry A. ^{[3
]}

Feng, Wenzheng ^{[4
]}

Gates, Vanessa L. ^{[5
]}

Halama, James ^{[6
]}

Kennedy, Andrew S. ^{[7
]}

Nag, Subir ^{[8
]}

Sarfaraz, Mehrdad ^{[9
]}

Sehgal, Varun ^{[10
]}

Selwyn, Reed ^{[11
]}

Stabin, Michael G. ^{[12
]}

Thomadsen, Bruce R. ^{[13
]}

Williams, Lawrence E. ^{[14
]}

Salem, Riad ^{[5
]}

机构：

[1] Med Radiat Phys Inc, Milford, OH 45150 USA

[2] Natl Inst Stand & Technol, Phys Lab, Gaithersburg, MD 20899 USA

[3] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA

[4] William Beaumont Hosp, Heart & Vasc Ctr, Royal Oak, MI 48073 USA

[5] NW Mem Hosp, Div Intervent Radiol, Dept Radiol, Chicago, IL 60611 USA

[6] Loyola Univ, Med Ctr, Maywood, IL 60153 USA

[7] Wake Radiol Oncol Serv, Cary, NC 27518 USA

[8] Kaiser Permanente Radiat Oncol, Santa Clara, CA 95051 USA

[9] Greater Baltimore Med Ctr, Dept Radiat Oncol, Baltimore, MD 21204 USA

[10] Univ Calif, Dept Radiat Oncol, Irvine Med Ctr, Orange, CA 92868 USA

[11] Uniformed Serv Univ Hlth Sci, Radiol & Radiol Sci Dept, Bethesda, MD 20814 USA

[12] Vanderbilt Univ, Dept Radiol & Radiol Sci, Nashville, TN 37232 USA

[13] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA

[14] City Hope Med Ctr, Duarte, CA 91010 USA

来源：

MEDICAL PHYSICS | 2011年 / 38卷 / 08期

关键词：

yttrium; microsphere; brachytherapy; radioembolization; liver; dosimetry; imaging; LIVER METASTASES; CLINICAL-EVALUATION; PARTITION MODEL; RADIATION; THERAPY; SPECT; RADIOEMBOLIZATION; RATIO; STANDARDIZATION; IMPLEMENTATION;

D O I：

10.1118/1.3608909

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Yttrium-90 microsphere brachytherapy of the liver exploits the distinctive features of the liver anatomy to treat liver malignancies with beta radiation and is gaining more wide spread clinical use. This report provides a general overview of microsphere liver brachytherapy and assists the treatment team in creating local treatment practices to provide safe and efficient patient treatment. Suggestions for future improvements are incorporated with the basic rationale for the therapy and currently used procedures. Imaging modalities utilized and their respective quality assurance are discussed. General as well as vendor specific delivery procedures are reviewed. The current dosimetry models are reviewed and suggestions for dosimetry advancement are made. Beta activity standards are reviewed and vendor implementation strategies are discussed. Radioactive material licensing and radiation safety are discussed given the unique requirements of microsphere brachytherapy. A general, team-based quality assurance program is reviewed to provide guidance for the creation of the local procedures. Finally, recommendations are given on how to deliver the current state of the art treatments and directions for future improvements in the therapy. (C) 2011 American Association of Physicists in Medicine. [DOI: 10.1118/1.3608909]

引用

页码：4824 / 4845

页数：22

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