Utility of COVID-19 antigen testing in the emergency department

被引：12

作者：

Peacock, W. Frank ^{[1
]}

Soto-Ruiz, Karina M. ^{[2
]}

House, Stacey L. ^{[3
]}

Cannon, Chad M. ^{[4
]}

Headden, Gary ^{[5
]}

Tiffany, Brian ^{[6
]}

Motov, Sergey ^{[7
]}

Merchant-Borna, Kian ^{[8
]}

Chang, Anna Marie ^{[9
]}

Pearson, Claire ^{[10
]}

Patterson, Brian W. ^{[11
]}

Jones, Alan E. ^{[12
]}

Miller, Joseph ^{[13
]}

Varon, Joseph ^{[14
]}

Bastani, Aveh ^{[15
]}

Clark, Carol ^{[16
]}

Rafique, Zubaid ^{[1
]}

Kea, Bory ^{[17
]}

Eppensteiner, John ^{[18
]}

Williams, James M. ^{[19
]}

Mahler, Simon A. ^{[20
]}

Driver, Brian E. ^{[21
]}

Hendry, Phyllis ^{[22
]}

Quackenbush, Eugenia ^{[23
]}

Robinson, David ^{[24
]}

Schrock, Jon W. ^{[25
]}

D'Etienne, James P. ^{[26
]}

Hogan, Christopher J. ^{[27
,28
]}

Osborne, Anwar ^{[29
]}

Riviello, Ralph ^{[30
]}

Young, Stephen ^{[31
]}

机构：

[1] Baylor Coll Med, Dept Emergency Med, Houston, TX 77030 USA

[2] Comprehens Res Associates LLC, Houston, TX USA

[3] Washington Univ, Sch Med, Dept Emergency Med, St Louis, MO USA

[4] Univ Kansas, Med Ctr, Dept Emergency Med, Kansas City, KS 66103 USA

[5] Med Univ South Carolina, Dept Emergency Med, Charleston, SC 29425 USA

[6] Dign Hlth Res Inst, Phoenix, AZ USA

[7] Maimonides Hosp, Dept Emergency Med, Brooklyn, NY 11219 USA

[8] Univ Rochester, Sch Med & Dent, Med Ctr, Dept Emergency Med, Rochester, NY USA

[9] Thomas Jefferson Univ, Dept Emergency Med, Philadelphia, PA 19107 USA

[10] Wayne State Univ, Ascens St John, Dept Emergency Med, Detroit, MI USA

[11] Univ Wisconsin, Dept Emergency Med, Sch Med & Publ Hlth, Madison, WI USA

[12] Univ Mississippi, Med Ctr, Dept Emergency Med, Jackson, MS 39216 USA

[13] Henry Ford Hosp, Dept Emergency Med, Detroit, MI 48202 USA

[14] Univ Houston, Sch Med, United Mem Med Ctr, Dept Intens Care Med, Houston, TX USA

[15] William Beaumont Hlth Syst, Dept Emergency Med, Troy, MI USA

[16] William Beaumont Hlth Syst, Dept Emergency Med, Royal Oak, MI USA

[17] Oregon Hlth & Sci Univ, Dept Emergency Med, Portland, OR 97201 USA

[18] Duke Univ, Dept Emergency Med, Durham, NC USA

[19] Texas Tech Univ, Hlth Sci Ctr, Sch Med, Meritus Med Ctr,Dept Emergency Med, Lubbock, TX 79430 USA

[20] Wake Forest Sch Med, Dept Emergency Med, Winston Salem, NC 27101 USA

[21] Hennepin Cty Med Ctr, Dept Emergency Med, Minneapolis, MN 55415 USA

[22] Univ Florida, Coll Med, Dept Emergency Med, Jacksonville, FL USA

[23] Univ N Carolina, Dept Emergency Med, Sch Med, Chapel Hill, NC USA

[24] Univ Texas Houston, Dept Emergency Med, McGovern Med Sch, Houston, TX USA

[25] Case Western Reserve Univ, Sch Med, MetroHlth Med Ctr, Dept Emergency Med, Cleveland, OH USA

[26] John Peter Smith Hlth Network, Integrat Emergency Serv, Ft Worth, TX USA

[27] Virginia Commonwealth Univ, Med Ctr, Dept Emergency Med, Richmond, VA USA

[28] Virginia Commonwealth Univ, Med Ctr, Dept Surg, Richmond, VA USA

[29] Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA USA

[30] Univ Texas Hlth San Antonio, Dept Emergency Med, San Antonio, TX USA

[31] TriCore Reference Labs, Albuquerque, NM USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN | 2022年 / 3卷 / 01期

关键词：

antigen testing; Covid-19; diagnostic devices; emergency department; nasal swab; point of care;

D O I：

10.1002/emp2.12605

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background The BinaxNOW coronavirus disease 2019 (COVID-19) Ag Card test (Abbott Diagnostics Scarborough, Inc.) is a lateral flow immunochromatographic point-of-care test for the qualitative detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein antigen. It provides results from nasal swabs in 15 minutes. Our purpose was to determine its sensitivity and specificity for a COVID-19 diagnosis. Methods Eligible patients had symptoms of COVID-19 or suspected exposure. After consent, 2 nasal swabs were collected; 1 was tested using the Abbott RealTime SARS-CoV-2 (ie, the gold standard polymerase chain reaction test) and the second run on the BinaxNOW point of care platform by emergency department staff. Results From July 20 to October 28, 2020, 767 patients were enrolled, of which 735 had evaluable samples. Their mean (SD) age was 46.8 (16.6) years, and 422 (57.4%) were women. A total of 623 (84.8%) patients had COVID-19 symptoms, most commonly shortness of breath (n = 404; 55.0%), cough (n = 314; 42.7%), and fever (n = 253; 34.4%). Although 460 (62.6%) had symptoms <= 7 days, the mean (SD) time since symptom onset was 8.1 (14.0) days. Positive tests occurred in 173 (23.5%) and 141 (19.2%) with the gold standard versus BinaxNOW test, respectively. Those with symptoms >2 weeks had a positive test rate roughly half of those with earlier presentations. In patients with symptoms <= 7 days, the sensitivity, specificity, and negative and positive predictive values for the BinaxNOW test were 84.6%, 98.5%, 94.9%, and 95.2%, respectively. Conclusions The BinaxNOW point-of-care test has good sensitivity and excellent specificity for the detection of COVID-19. We recommend using the BinasNOW for patients with symptoms up to 2 weeks.

引用

页数：8

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