Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

被引：53
|
作者：
Zhu, Xianchun [1 ]
Lu, Wentong [1 ]
Zhang, Yazhou [1 ]
Reed, Aisha [1 ]
Newton, Brandon [1 ]
Fan, Zhen [1 ]
Yu, Hongtao [1 ]
Ray, Paresh C. [1 ]
Gao, Ruomei [1 ]
机构：
[1] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39211 USA
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 37期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
SINGLET OXYGEN PRODUCTION; TRIPLET-STATE CHARACTERISTICS; PHOTOSENSITIZERS; WATER; LUMINESCENCE; EXCITATION; BINDING; DNA;
D O I：
10.1039/c1cc13328d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
5,10,15,20-Tetrakis(N-(2-(1H-imidazol-4-yl)ethyl)benzamide)porphyrin produced twice as many singlet oxygen ((1)O(2)) molecules at pH 5.0 (quantum yield 0.53 +/- 0.01) than at pH 7.4, whereas the (1)O(2) quenching rate was reduced by a factor of 2.5 for a pH change from 7.4 to 5.0.
引用
收藏
页码：10311 / 10313
页数：3
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