Synthesis of dipyrrolo[2,3-a:1′,2′,3′-fg]acridin-12(1H)-ones

被引：4

作者：

Beyer, Renee L. ^{[1
]}

Kandemir, Hakan ^{[1
,2
]}

Bhadbhade, Mohan ^{[1
]}

Sengul, Ibrahim F. ^{[1
,3
]}

Leu, Chao-Wei ^{[1
]}

Wenholz, Daniel ^{[1
]}

Kumar, Naresh ^{[1
]}

Black, David StC ^{[1
]}

机构：

[1] Univ New South Wales, Sch Chem, UNSW Sydney, Sydney, NSW 2052, Australia

[2] Namik Kemal Univ, Fac Art & Sci, Dept Chem, Tekirdag, Turkey

[3] Gebze Tech Univ, Fac Sci, Dept Chem, Gebze, Kocaeli, Turkey

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 51期

关键词：

Acylation; Decarbonylation; Acridones; Indoles; Pyrroloindoles; Pyrroloacridones; INDOLES;

D O I：

10.1016/j.tetlet.2018.11.011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acylation reactions of 4,6-dimethoxyindoles with glyoxyloyl chlorides were achieved by the use of graphite powder in 1,2-dichloroethane at reflux. The products were monoketones as a result of decarbonylation, rather than the expected 1,2-diketones. Treatment of these monoketones with base led to their cyclisation and elimination of methanol to afford the novel dipyrrolo[2.3-a:1',2',3'-fg]acridin-12(1H)-ones. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：4483 / 4486

页数：4

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