Metabolism unhinged: IDH mutations in cancer

被引：136

作者：

Prensner, John R. ^{[1
,2
]}

Chinnaiyan, Arul M. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Michigan Ctr Translat Pathol, Ann Arbor, MI USA

[3] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI USA

[4] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

NATURE MEDICINE | 2011年 / 17卷 / 03期

关键词：

ACUTE MYELOID-LEUKEMIA;

D O I：

10.1038/nm0311-291

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：291 / 293

页数：4

共 12 条

[1] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate [J].

Dang, Lenny ;

White, David W. ;

Gross, Stefan ;

Bennett, Bryson D. ;

Bittinger, Mark A. ;

Driggers, Edward M. ;

Fantin, Valeria R. ;

Jang, Hyun Gyung ;

Jin, Shengfang ;

Keenan, Marie C. ;

Marks, Kevin M. ;

Prins, Robert M. ;

Ward, Patrick S. ;

Yen, Katharine E. ;

Liau, Linda M. ;

Rabinowitz, Joshua D. ;

Cantley, Lewis C. ;

Thompson, Craig B. ;

Heiden, Matthew G. Vander ;

Su, Shinsan M. .

NATURE, 2009, 462 (7274) :739-U52

[2] Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation [J].

Figueroa, Maria E. ;

Abdel-Wahab, Omar ;

Lu, Chao ;

Ward, Patrick S. ;

Patel, Jay ;

Shih, Alan ;

Li, Yushan ;

Bhagwat, Neha ;

Vasanthakumar, Aparna ;

Fernandez, Hugo F. ;

Tallman, Martin S. ;

Sun, Zhuoxin ;

Wolniak, Kristy ;

Peeters, Justine K. ;

Liu, Wei ;

Choe, Sung E. ;

Fantin, Valeria R. ;

Paietta, Elisabeth ;

Lowenberg, Bob ;

Licht, Jonathan D. ;

Godley, Lucy A. ;

Delwel, Ruud ;

Valk, Peter J. M. ;

Thompson, Craig B. ;

Levine, Ross L. ;

Melnick, An .

CANCER CELL, 2010, 18 (06) :553-567

[3] Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome [J].

Mardis, Elaine R. ;

Ding, Li ;

Dooling, David J. ;

Larson, David E. ;

McLellan, Michael D. ;

Chen, Ken ;

Koboldt, Daniel C. ;

Fulton, Robert S. ;

Delehaunty, Kim D. ;

McGrath, Sean D. ;

Fulton, Lucinda A. ;

Locke, Devin P. ;

Magrini, Vincent J. ;

Abbott, Rachel M. ;

Vickery, Tammi L. ;

Reed, Jerry S. ;

Robinson, Jody S. ;

Wylie, Todd ;

Smith, Scott M. ;

Carmichael, Lynn ;

Eldred, James M. ;

Harris, Christopher C. ;

Walker, Jason ;

Peck, Joshua B. ;

Du, Feiyu ;

Dukes, Adam F. ;

Sanderson, Gabriel E. ;

Brummett, Anthony M. ;

Clark, Eric ;

McMichael, Joshua F. ;

Meyer, Rick J. ;

Schindler, Jonathan K. ;

Pohl, Craig S. ;

Wallis, John W. ;

Shi, Xiaoqi ;

Lin, Ling ;

Schmidt, Heather ;

Tang, Yuzhu ;

Haipek, Carrie ;

Wiechert, Madeline E. ;

Ivy, Jolynda V. ;

Kalicki, Joelle ;

Elliott, Glendoria ;

Ries, Rhonda E. ;

Payton, Jacqueline E. ;

Westervelt, Peter ;

Tomasson, Michael H. ;

Watson, Mark A. ;

Baty, Jack ;

Heath, Sharon .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (11) :1058-1066

[4] Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma [J].

Noushmehr, Houtan ;

Weisenberger, Daniel J. ;

Diefes, Kristin ;

Phillips, Heidi S. ;

Pujara, Kanan ;

Berman, Benjamin P. ;

Pan, Fei ;

Pelloski, Christopher E. ;

Sulman, Erik P. ;

Bhat, Krishna P. ;

Verhaak, Roel G. W. ;

Hoadley, Katherine A. ;

Hayes, D. Neil ;

Perou, Charles M. ;

Schmidt, Heather K. ;

Ding, Li ;

Wilson, Richard K. ;

Van Den Berg, David ;

Shen, Hui ;

Bengtsson, Henrik ;

Neuvial, Pierre ;

Cope, Leslie M. ;

Buckley, Jonathan ;

Herman, James G. ;

Baylin, Stephen B. ;

Laird, Peter W. ;

Aldape, Kenneth .

CANCER CELL, 2010, 17 (05) :510-522

[5] An integrated genomic analysis of human glioblastoma Multiforme [J].

Parsons, D. Williams ;

Jones, Sian ;

Zhang, Xiaosong ;

Lin, Jimmy Cheng-Ho ;

Leary, Rebecca J. ;

Angenendt, Philipp ;

Mankoo, Parminder ;

Carter, Hannah ;

Siu, I-Mei ;

Gallia, Gary L. ;

Olivi, Alessandro ;

McLendon, Roger ;

Rasheed, B. Ahmed ;

Keir, Stephen ;

Nikolskaya, Tatiana ;

Nikolsky, Yuri ;

Busam, Dana A. ;

Tekleab, Hanna ;

Diaz, Luis A., Jr. ;

Hartigan, James ;

Smith, Doug R. ;

Strausberg, Robert L. ;

Marie, Suely Kazue Nagahashi ;

Shinjo, Sueli Mieko Oba ;

Yan, Hai ;

Riggins, Gregory J. ;

Bigner, Darell D. ;

Karchin, Rachel ;

Papadopoulos, Nick ;

Parmigiani, Giovanni ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

Kinzler, Kenneth W. .

SCIENCE, 2008, 321 (5897) :1807-1812

[6] IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication [J].

Paschka, Peter ;

Schlenk, Richard F. ;

Gaidzik, Verena I. ;

Habdank, Marianne ;

Kroenke, Jan ;

Bullinger, Lars ;

Spaeth, Daniela ;

Kayser, Sabine ;

Zucknick, Manuela ;

Goetze, Katharina ;

Horst, Heinz-A. ;

Germing, Ulrich ;

Doehner, Hartmut ;

Doehner, Konstanze .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (22) :3636-3643

[7] Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression [J].

Sreekumar, Arun ;

Poisson, Laila M. ;

Rajendiran, Thekkelnaycke M. ;

Khan, Amjad P. ;

Cao, Qi ;

Yu, Jindan ;

Laxman, Bharathi ;

Mehra, Rohit ;

Lonigro, Robert J. ;

Li, Yong ;

Nyati, Mukesh K. ;

Ahsan, Aarif ;

Kalyana-Sundaram, Shanker ;

Han, Bo ;

Cao, Xuhong ;

Byun, Jaeman ;

Omenn, Gilbert S. ;

Ghosh, Debashis ;

Pennathur, Subramaniam ;

Alexander, Danny C. ;

Berger, Alvin ;

Shuster, Jeffrey R. ;

Wei, John T. ;

Varambally, Sooryanarayana ;

Beecher, Christopher ;

Chinnaiyan, Arul M. .

NATURE, 2009, 457 (7231) :910-914

[8] The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate [J].

Ward, Patrick S. ;

Patel, Jay ;

Wise, David R. ;

Abdel-Wahab, Omar ;

Bennett, Bryson D. ;

Coller, Hilary A. ;

Cross, Justin R. ;

Fantin, Valeria R. ;

Hedvat, Cyrus V. ;

Perl, Alexander E. ;

Rabinowitz, Joshua D. ;

Carroll, Martin ;

Su, Shinsan M. ;

Sharp, Kim A. ;

Levine, Ross L. ;

Thompson, Craig B. .

CANCER CELL, 2010, 17 (03) :225-234

[9] Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases [J].

Xu, Wei ;

Yang, Hui ;

Liu, Ying ;

Yang, Ying ;

Wang, Ping ;

Kim, Se-Hee ;

Ito, Shinsuke ;

Yang, Chen ;

Wang, Pu ;

Xiao, Meng-Tao ;

Liu, Li-xia ;

Jiang, Wen-qing ;

Liu, Jing ;

Zhang, Jin-ye ;

Wang, Bin ;

Frye, Stephen ;

Zhang, Yi ;

Xu, Yan-hui ;

Lei, Qun-ying ;

Guan, Kun-Liang ;

Zhao, Shi-min ;

Xiong, Yue .

CANCER CELL, 2011, 19 (01) :17-30

[10] IDH1 and IDH2 Mutations in Gliomas [J].

Yan, Hai ;

Parsons, D. Williams ;

Jin, Genglin ;

McLendon, Roger ;

Rasheed, B. Ahmed ;

Yuan, Weishi ;

Kos, Ivan ;

Batinic-Haberle, Ines ;

Jones, Sian ;

Riggins, Gregory J. ;

Friedman, Henry ;

Friedman, Allan ;

Reardon, David ;

Herndon, James ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. ;

Vogelstein, Bert ;

Bigner, Darell D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (08) :765-773

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