Metabolism unhinged: IDH mutations in cancer

被引：135
作者：
Prensner, John R. [1 ,2 ]
Chinnaiyan, Arul M. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Michigan Ctr Translat Pathol, Ann Arbor, MI USA
[3] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI USA
[4] Howard Hughes Med Inst, Chevy Chase, MD USA
来源：
NATURE MEDICINE | 2011年 / 17卷 / 03期
关键词：
ACUTE MYELOID-LEUKEMIA;
D O I：
10.1038/nm0311-291
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：291 / 293
页数：4
相关论文
共 12 条
  • [1] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    Dang, Lenny
    White, David W.
    Gross, Stefan
    Bennett, Bryson D.
    Bittinger, Mark A.
    Driggers, Edward M.
    Fantin, Valeria R.
    Jang, Hyun Gyung
    Jin, Shengfang
    Keenan, Marie C.
    Marks, Kevin M.
    Prins, Robert M.
    Ward, Patrick S.
    Yen, Katharine E.
    Liau, Linda M.
    Rabinowitz, Joshua D.
    Cantley, Lewis C.
    Thompson, Craig B.
    Heiden, Matthew G. Vander
    Su, Shinsan M.
    [J]. NATURE, 2009, 462 (7274) : 739 - U52
  • [2] Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
    Figueroa, Maria E.
    Abdel-Wahab, Omar
    Lu, Chao
    Ward, Patrick S.
    Patel, Jay
    Shih, Alan
    Li, Yushan
    Bhagwat, Neha
    Vasanthakumar, Aparna
    Fernandez, Hugo F.
    Tallman, Martin S.
    Sun, Zhuoxin
    Wolniak, Kristy
    Peeters, Justine K.
    Liu, Wei
    Choe, Sung E.
    Fantin, Valeria R.
    Paietta, Elisabeth
    Lowenberg, Bob
    Licht, Jonathan D.
    Godley, Lucy A.
    Delwel, Ruud
    Valk, Peter J. M.
    Thompson, Craig B.
    Levine, Ross L.
    Melnick, An
    [J]. CANCER CELL, 2010, 18 (06) : 553 - 567
  • [3] Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
    Mardis, Elaine R.
    Ding, Li
    Dooling, David J.
    Larson, David E.
    McLellan, Michael D.
    Chen, Ken
    Koboldt, Daniel C.
    Fulton, Robert S.
    Delehaunty, Kim D.
    McGrath, Sean D.
    Fulton, Lucinda A.
    Locke, Devin P.
    Magrini, Vincent J.
    Abbott, Rachel M.
    Vickery, Tammi L.
    Reed, Jerry S.
    Robinson, Jody S.
    Wylie, Todd
    Smith, Scott M.
    Carmichael, Lynn
    Eldred, James M.
    Harris, Christopher C.
    Walker, Jason
    Peck, Joshua B.
    Du, Feiyu
    Dukes, Adam F.
    Sanderson, Gabriel E.
    Brummett, Anthony M.
    Clark, Eric
    McMichael, Joshua F.
    Meyer, Rick J.
    Schindler, Jonathan K.
    Pohl, Craig S.
    Wallis, John W.
    Shi, Xiaoqi
    Lin, Ling
    Schmidt, Heather
    Tang, Yuzhu
    Haipek, Carrie
    Wiechert, Madeline E.
    Ivy, Jolynda V.
    Kalicki, Joelle
    Elliott, Glendoria
    Ries, Rhonda E.
    Payton, Jacqueline E.
    Westervelt, Peter
    Tomasson, Michael H.
    Watson, Mark A.
    Baty, Jack
    Heath, Sharon
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (11) : 1058 - 1066
  • [4] Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
    Noushmehr, Houtan
    Weisenberger, Daniel J.
    Diefes, Kristin
    Phillips, Heidi S.
    Pujara, Kanan
    Berman, Benjamin P.
    Pan, Fei
    Pelloski, Christopher E.
    Sulman, Erik P.
    Bhat, Krishna P.
    Verhaak, Roel G. W.
    Hoadley, Katherine A.
    Hayes, D. Neil
    Perou, Charles M.
    Schmidt, Heather K.
    Ding, Li
    Wilson, Richard K.
    Van Den Berg, David
    Shen, Hui
    Bengtsson, Henrik
    Neuvial, Pierre
    Cope, Leslie M.
    Buckley, Jonathan
    Herman, James G.
    Baylin, Stephen B.
    Laird, Peter W.
    Aldape, Kenneth
    [J]. CANCER CELL, 2010, 17 (05) : 510 - 522
  • [5] An integrated genomic analysis of human glioblastoma Multiforme
    Parsons, D. Williams
    Jones, Sian
    Zhang, Xiaosong
    Lin, Jimmy Cheng-Ho
    Leary, Rebecca J.
    Angenendt, Philipp
    Mankoo, Parminder
    Carter, Hannah
    Siu, I-Mei
    Gallia, Gary L.
    Olivi, Alessandro
    McLendon, Roger
    Rasheed, B. Ahmed
    Keir, Stephen
    Nikolskaya, Tatiana
    Nikolsky, Yuri
    Busam, Dana A.
    Tekleab, Hanna
    Diaz, Luis A., Jr.
    Hartigan, James
    Smith, Doug R.
    Strausberg, Robert L.
    Marie, Suely Kazue Nagahashi
    Shinjo, Sueli Mieko Oba
    Yan, Hai
    Riggins, Gregory J.
    Bigner, Darell D.
    Karchin, Rachel
    Papadopoulos, Nick
    Parmigiani, Giovanni
    Vogelstein, Bert
    Velculescu, Victor E.
    Kinzler, Kenneth W.
    [J]. SCIENCE, 2008, 321 (5897) : 1807 - 1812
  • [6] IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication
    Paschka, Peter
    Schlenk, Richard F.
    Gaidzik, Verena I.
    Habdank, Marianne
    Kroenke, Jan
    Bullinger, Lars
    Spaeth, Daniela
    Kayser, Sabine
    Zucknick, Manuela
    Goetze, Katharina
    Horst, Heinz-A.
    Germing, Ulrich
    Doehner, Hartmut
    Doehner, Konstanze
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (22) : 3636 - 3643
  • [7] Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
    Sreekumar, Arun
    Poisson, Laila M.
    Rajendiran, Thekkelnaycke M.
    Khan, Amjad P.
    Cao, Qi
    Yu, Jindan
    Laxman, Bharathi
    Mehra, Rohit
    Lonigro, Robert J.
    Li, Yong
    Nyati, Mukesh K.
    Ahsan, Aarif
    Kalyana-Sundaram, Shanker
    Han, Bo
    Cao, Xuhong
    Byun, Jaeman
    Omenn, Gilbert S.
    Ghosh, Debashis
    Pennathur, Subramaniam
    Alexander, Danny C.
    Berger, Alvin
    Shuster, Jeffrey R.
    Wei, John T.
    Varambally, Sooryanarayana
    Beecher, Christopher
    Chinnaiyan, Arul M.
    [J]. NATURE, 2009, 457 (7231) : 910 - 914
  • [8] The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
    Ward, Patrick S.
    Patel, Jay
    Wise, David R.
    Abdel-Wahab, Omar
    Bennett, Bryson D.
    Coller, Hilary A.
    Cross, Justin R.
    Fantin, Valeria R.
    Hedvat, Cyrus V.
    Perl, Alexander E.
    Rabinowitz, Joshua D.
    Carroll, Martin
    Su, Shinsan M.
    Sharp, Kim A.
    Levine, Ross L.
    Thompson, Craig B.
    [J]. CANCER CELL, 2010, 17 (03) : 225 - 234
  • [9] Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
    Xu, Wei
    Yang, Hui
    Liu, Ying
    Yang, Ying
    Wang, Ping
    Kim, Se-Hee
    Ito, Shinsuke
    Yang, Chen
    Wang, Pu
    Xiao, Meng-Tao
    Liu, Li-xia
    Jiang, Wen-qing
    Liu, Jing
    Zhang, Jin-ye
    Wang, Bin
    Frye, Stephen
    Zhang, Yi
    Xu, Yan-hui
    Lei, Qun-ying
    Guan, Kun-Liang
    Zhao, Shi-min
    Xiong, Yue
    [J]. CANCER CELL, 2011, 19 (01) : 17 - 30
  • [10] IDH1 and IDH2 Mutations in Gliomas
    Yan, Hai
    Parsons, D. Williams
    Jin, Genglin
    McLendon, Roger
    Rasheed, B. Ahmed
    Yuan, Weishi
    Kos, Ivan
    Batinic-Haberle, Ines
    Jones, Sian
    Riggins, Gregory J.
    Friedman, Henry
    Friedman, Allan
    Reardon, David
    Herndon, James
    Kinzler, Kenneth W.
    Velculescu, Victor E.
    Vogelstein, Bert
    Bigner, Darell D.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (08) : 765 - 773
12