Two Cases of Cancer-associated Retinopathy Combined with Small-cell Lung Cancer

被引：16

作者：

Sakamori, Yuichi ^{[1
]}

Kim, Young Hak ^{[1
]}

Okuda, Chiyuki ^{[1
]}

Togashi, Yosuke ^{[1
]}

Kinose, Daisuke ^{[1
]}

Masago, Katsuhiro ^{[1
]}

Mio, Tadashi ^{[1
]}

Uji, Akihito ^{[2
]}

Mishima, Michiaki ^{[1
]}

机构：

[1] Kyoto Univ, Dept Resp Med, Grad Sch Med, Kyoto, Japan

[2] Kyoto Univ, Dept Ophthalmol & Visual Sci, Kyoto, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2011年 / 41卷 / 05期

关键词：

small-cell lung cancer; cancer-associated retinopathy; paraneoplastic syndrome; recoverin; corticosteroid; PARANEOPLASTIC RETINOPATHY; CARCINOMA; RECOVERIN; PATIENT;

D O I：

10.1093/jjco/hyr025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer-associated retinopathy is a rare paraneoplastic syndrome that is often associated with small-cell lung cancer. It is caused by an autoantibody to the 23 kDa photoreceptor protein, recoverin. A small number of reports have described effective treatment for the disease. We report two cases of cancer-associated retinopathy with small-cell lung cancer whose visual symptom preceded the diagnosis of cancer. Their visual acuity and visual field were slightly improved after steroid and anticancer therapy. Steroid therapy was effective, although the period from visual symptom onset to therapy was comparative longer. When cancer-associated retinopathy is suspected, a comparatively large quantity of steroids and anticancer treatment should be combined immediately.

引用

页码：669 / 673

页数：5

共 20 条

[1] The occurrence of serum autoantibodies against enolase in cancer-associated retinopathy [J].

Adamus, G ;

Aptsiauri, N ;

Guy, J ;

Heckenlively, J ;

Flannery, J ;

Hargrave, PA .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1996, 78 (02) :120-129

[2] Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy [J].

Adamus G. ;

Ren G. ;

Weleber R.G. .

BMC Ophthalmology, 4 (1) :1-9

[3]

Boucher MC, 1997, CAN J OPHTHALMOL, V32, P46

[4]

Guy J, 1999, ARCH OPHTHALMOL-CHIC, V117, P471

[5] A CLINICAL TRIAD TO DIAGNOSE PARANEOPLASTIC RETINOPATHY [J].

JACOBSON, DM ;

THIRKILL, CE ;

TIPPING, SJ .

ANNALS OF NEUROLOGY, 1990, 28 (02) :162-167

[6] Cancer-associated retinopathy during treatment for small-cell lung carcinoma [J].

Kashiwabara, K ;

Nakamura, H ;

Kishi, K ;

Yagyu, H ;

Sarashina, G ;

Kobayashi, K ;

Matsuoka, T .

INTERNAL MEDICINE, 1999, 38 (07) :597-601

[7] MANAGEMENT AND MONITORING OF CANCER-ASSOCIATED RETINOPATHY [J].

KELTNER, JL ;

THIRKILL, CE ;

TYLER, NK ;

ROTH, AM .

ARCHIVES OF OPHTHALMOLOGY, 1992, 110 (01) :48-53

[8] Long-term survival of a patient with small cell lung cancer associated with cancer-associated retinopathy [J].

Kobayashi, Makoto ;

Ikezoe, Takayuki ;

Uemura, Yoshiki ;

Ueno, Hisayuki ;

Taguchi, Hirokuni .

LUNG CANCER, 2007, 57 (03) :399-403

[9] Cancer-associated retinopathy syndrome: A case of small cell lung cancer expressing recoverin immunoreactivity [J].

Matsubara, S ;

Yamaji, Y ;

Fujita, T ;

Kanayama, T ;

Yamadori, I ;

Sato, M ;

Fujita, J ;

Shiotani, T ;

Takahara, J .

LUNG CANCER, 1996, 14 (2-3) :265-271

[10]

Murphy MA, 1997, J NEURO-OPHTHALMOL, V17, P77

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