Carbamate-linked cationic lipids for gene delivery

被引：11

作者：

Liu, Dongliang ^{[1
]}

Qiao, Weihong ^{[2
]}

Li, Zongshi ^{[2
]}

Cui, Xiuyun ^{[3
]}

Li, Kun ^{[3
]}

Yu, Lihua ^{[3
]}

Yan, Kelu ^{[1
]}

Zhu, Limin ^{[1
]}

Cheng, Lvbo ^{[2
]}

机构：

[1] Donghua Univ, Minist Educ, Key Lab Sci & Technol Ecotext, Shanghai 201620, Peoples R China

[2] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

[3] Dalian Med Univ, Dept Biol Chem & Mol Biol, Dalian 116027, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 02期

关键词：

carbamate-linked; cationic lipids; transfection; gene delivery;

D O I：

10.1016/j.bmc.2007.10.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Series of cationic lipids 1a-p, with variable length of hydrocarbon chains, alternative quaternary ammonium heads, carbamate linkages between hydrocarbon chains and quaternary ammonium heads, as well as different anion combined with them, were synthesized for liposome-mediated gene delivery. Two plasmid DNAs, pGL3-control and pGFP-N2, were transferred by cationic liposomes formed from the above cationic lipids into five mammalian cell lines, and the transfection efficiency of some of the cationic liposomes was superior or parallel to that of two commercial transfection agents, Lipofectamine2000 (TM) and Sofast (TM). (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：995 / 1005

页数：11

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