Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water

被引：22

作者：

Kumar, Siripuram Vijay ^{[1
]}

Ma, Dawei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Ctr Excellence Mol Synth,Univ Chinese Acad Sci, 345 Lingling Lu, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2018年 / 36卷 / 11期

基金：

中国国家自然科学基金;

关键词：

hydrazine hydrate; cross-coupling; aryl halides; ligand effects; copper; synthetic methods; (HETERO)ARYL CHLORIDES; EFFICIENT SYNTHESIS; AMINATION; CHEMISTRY; AMINES; SCOPE;

D O I：

10.1002/cjoc.201800326

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The N,N'-bis(2,6-dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu-catalyzed cross-coupling of aryl halides with hydrazine hydrate, leading to the formation of a variety of aryl hydrazines at 80 C-o in water under the assistance of K3PO4 and 4 mol% cetyltrimethylammonium bromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases.

引用

页码：1003 / 1006

页数：4

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