C-7 Oxygenated Coumarins from the Fruits of Micromelum minutum

被引：20

作者：

Lekphrom, Ratsami ^{[1
,2
]}

Kanokmedhakul, Somdej ^{[1
,2
]}

Kukongviriyapan, Veerapol ^{[3
]}

Kanokmedhakul, Kwanjai ^{[1
,2
]}

机构：

[1] Khon Kaen Univ, Fac Sci, Nat Prod Res Unit, Dept Chem, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Fac Sci, Ctr Innovat Chem, Khon Kaen 40002, Thailand

[3] Khon Kaen Univ, Fac Med, Dept Pharmacol, Khon Kaen 40002, Thailand

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 04期

关键词：

Micromelum minutum; Rutaceae; Coumarin; Cytotoxicity; Cholangiocarcinoma; RUTACEAE; PHEBALOSIN;

D O I：

10.1007/s12272-011-0402-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new 7-oxygenated coumarin, 7-demethylmurralonginol isovalerate (1), and a new natural product, murralonginol (2), together with seven known 7-oxygenated coumarins, murralonginol isovalerate (3), murralongin (4), micromelin (5), scopoletin (6), microminutin (7), murrangatin (8), and minumicrolin (9), were isolated from the fruits of Micromelum minutum. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data. Among these isolates, compounds 2 and 4 - 9 exhibited cytotoxicity against cholangiocarcinoma cell line, KKU-100.

引用

页码：527 / 531

页数：5

共 15 条

[1] POTENTIAL ANTI-TUMOR AGENTS .11. INVESTIGATION OF THE ANTI-TUMOR ACTIVITY OF MICROMELUM-INTEGERRIMUM (RUTACEAE) [J].

CASSADY, JM ;

OJIMA, N ;

CHANG, CJ ;

MCLAUGHLIN, JL .

JOURNAL OF NATURAL PRODUCTS, 1979, 42 (03) :274-278

[2]

Collins L., 1997, ANTIMICROBIAL AGENTS, V4, P1004

[3] 7-METHOXYCOUMARINS FROM MICROMELUM-MINUTUM [J].

DAS, S ;

BARUAH, RH ;

SHARMA, RP ;

BARUA, JN ;

KULANTHAIVEL, P ;

HERZ, W .

PHYTOCHEMISTRY, 1984, 23 (10) :2317-2321

[4]

IMAI F, 1986, CHEM PHARM BULL, V34, P3978

[5] THE CHEMICAL-COMPOSITION OF MURRAYA-PANICULATA - THE STRUCTURE OF 5 NEW COUMARINS AND ONE NEW ALKALOID AND THE STEREOCHEMISTRY OF MURRANGATIN AND RELATED COUMARINS [J].

ITO, C ;

FURUKAWA, H ;

ISHII, H ;

ISHIKAWA, T ;

HAGINIWA, J .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (07) :2047-2055

[6] Coumarins and dihydrocinnamic acid derivatives from Micromelum falcatum [J].

Kamperdick, C ;

Phuong, NM ;

Sung, TV ;

Schmidt, J ;

Adam, G .

PHYTOCHEMISTRY, 1999, 52 (08) :1671-1676

[7] MICROMELIN A NEW COUMARIN FROM MICROMELUM MINUTUM (FORST F) SEEM (FAMILY RUTACEAE) [J].

LAMBERTO.JA ;

PRICE, JR ;

REDCLIFF.AH .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1967, 20 (05) :973-&

[8] COUMARINS .10. SPECTRAL STUDIES ON SOME LINEAR FURANOCOUMARINS [J].

LEE, KH ;

SOINE, TO .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1969, 58 (06) :681-&

[9]

PONGBOONROD S, 1958, MAITET MUANG THAI, P624

[10] Coumarins from Malaysian Micromelum minutum [J].

Rahmani, M ;

Susidarti, RA ;

Ismail, HBM ;

Sukari, MA ;

Hin, TYY ;

Lian, GEC ;

Ali, AM ;

Kulip, J ;

Waterman, PG .

PHYTOCHEMISTRY, 2003, 64 (04) :873-877

← 1 2 →