Flavonoids, alkaloids from the seeds of Crotalaria pallida and their cytotoxicity and anti-inflammatory activities

被引：18
作者：
Hu, Xiu-Ren [1 ,2 ,3 ]
Chou, Gui-Xin [1 ,2 ,3 ]
Zhang, Cheng-Gang [1 ,2 ,3 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, MOE Key Lab Standardizat Chinese Med, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, SATCM Key Lab New Resources & Qual Evaluat Chines, Shanghai 201203, Peoples R China
[3] Shanghai R&D Ctr Standardizat Chinese Med, Shanghai 201203, Peoples R China
来源：
PHYTOCHEMISTRY | 2017年 / 143卷
基金：
中国国家自然科学基金;
关键词：
Crotalaria pallida (Leguminosae); Homoisoflavonoid; Alkaloid; Anti-inflammation; Cytotoxicity; PYRROLIZIDINE ALKALOIDS; ABIETANE DITERPENOIDS; CONSTITUENTS;
D O I：
10.1016/j.phytochem.2017.07.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three flavonoids, cropalliflavones A-C, including two homoisoflavonoids with rare skeletons; three previously undescribed alkaloids, usaramine-N-oxide and cropallins A-B; and sixteen known compounds, were isolated from the seeds of Crotalaria pallida Ait. The absolute configurations of cropalliflavone A and usaramine-N-oxide were established by an ECD calculation and X-ray crystallography, respectively. Additionally, cropalliflavone B showed anti-proliferative activity against the MCF-7 cell line with an IC50 value of 6.77 mu M, and cropalliflavone C showed anti-inflammatory activity, with an IC50 value of 16.07 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：64 / 71
页数：8
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