The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review

被引：33

作者：

Hulshof, Lianne A. ^{[1
]}

van Nuijs, Danny ^{[1
]}

Hol, Elly M. ^{[1
]}

Middeldorp, Jinte ^{[1
,2
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht Brain Ctr, Dept Translat Neurosci, Utrecht, Netherlands

[2] Biomed Primate Res Ctr, Dept Neurobiol & Aging, Rijswijk, Netherlands

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2022年 / 16卷

关键词：

Alzheimer's disease; astrocyte; synapse; dementia; synapse loss; systematic review; AMYLOID-BETA PEPTIDE; TAU-MEDIATED NEURODEGENERATION; GLIAL GLUTAMATE TRANSPORTER; ADENOSINE A(2A) RECEPTORS; HUMAN APOLIPOPROTEIN-E; MOUSE MODEL; A-BETA; PRECURSOR PROTEIN; NMDA RECEPTOR; D-SERINE;

D O I：

10.3389/fncel.2022.899251

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people worldwide. One pathological feature of progressing AD is the loss of synapses. This is the strongest correlate of cognitive decline. Astrocytes, as an essential part of the tripartite synapse, play a role in synapse formation, maintenance, and elimination. During AD, astrocytes get a reactive phenotype with an altered gene expression profile and changed function compared to healthy astrocytes. This process likely affects their interaction with synapses. This systematic review aims to provide an overview of the scientific literature including information on how astrocytes affect synapse formation and elimination in the brain of AD patients and in animal models of the disease. We review molecular and cellular changes in AD astrocytes and conclude that these predominantly result in lower synapse numbers, indicative of decreased synapse support or even synaptotoxicity, or increased elimination, resulting in synapse loss, and consequential cognitive decline, as associated with AD. Preventing AD induced changes in astrocytes might therefore be a potential therapeutic target for dementia.

引用

页数：17

共 130 条

[1] Thrombospondins: Multifunctional regulators of cell interactions [J].

Adams, JC .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2001, 17 :25-51

[2] Cell Biology of Astrocyte-Synapse Interactions [J].

Allen, Nicola J. ;

Eroglu, Cagla .

NEURON, 2017, 96 (03) :697-708

[3] ROLE OF ABNORMALLY PHOSPHORYLATED TAN IN THE BREAKDOWN OF MICROTUBULES IN ALZHEIMER-DISEASE [J].

ALONSO, AD ;

ZAIDI, T ;

GRUNDKEIQBAL, I ;

IQBAL, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (12) :5562-5566

[4] Early Stage Drug Treatment That Normalizes Proinflammatory Cytokine Production Attenuates Synaptic Dysfunction in a Mouse Model That Exhibits Age-Dependent Progression of Alzheimer's Disease-Related Pathology [J].

Bachstetter, Adam D. ;

Norris, Christopher M. ;

Sompol, Pradoldej ;

Wilcock, Donna M. ;

Goulding, Danielle ;

Neltner, Janna H. ;

Clair, Daret St. ;

Watterson, D. Martin ;

Van Eldik, Linda J. .

JOURNAL OF NEUROSCIENCE, 2012, 32 (30) :10201-10210

[5] Neurotoxic astrocytes express the D-serine synthesizing enzyme, serine racemase, in Alzheimer's disease [J].

Balu, Darrick T. ;

Pantazopoulos, Harry ;

Huang, Cathy C. Y. ;

Muszynski, Kevin ;

Harvey, Theresa Lynn ;

Uno, Yota ;

Rorabaugh, Jacki M. ;

Galloway, Claire R. ;

Botz-Zapp, Christian ;

Berretta, Sabina ;

Weinshenker, David ;

Coyle, Joseph T. .

NEUROBIOLOGY OF DISEASE, 2019, 130

[6] Astrocyte calcium signaling: the third wave [J].

Bazargani, Narges ;

Attwell, David .

NATURE NEUROSCIENCE, 2016, 19 (02) :182-189

[7] THE SELECTIVE AND COMPETITIVE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, (-)-6-PHOSPHONOMETHYL-DECA-HYDROISOQUINOLINE-3-CARBOXYLIC ACID, PREVENTS SYNAPTIC TOXICITY INDUCED BY AMYLOID-β IN MICE [J].

Bicca, M. A. ;

Figueiredo, C. P. ;

Piermartiri, T. C. ;

Meotti, F. C. ;

Bouzon, Z. L. ;

Tasca, C. I. ;

Medeiros, R. ;

Calixto, J. B. .

NEUROSCIENCE, 2011, 192 :631-641

[8] LOSS OF BRAIN 5-HT(2) RECEPTORS IN ALZHEIMERS-DISEASE - IN-VIVO ASSESSMENT WITH POSITRON EMISSION TOMOGRAPHY AND [F-18] SETOPERONE [J].

BLIN, J ;

BARON, JC ;

DUBOIS, B ;

CROUZEL, C ;

FIORELLI, M ;

ATTARLEVY, D ;

PILLON, B ;

FOURNIER, D ;

VIDAILHET, M ;

AGID, Y .

BRAIN, 1993, 116 :497-510

[9] The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain [J].

Boisvert, Matthew M. ;

Erikson, Galina A. ;

Shokhirev, Maxim N. ;

Allen, Nicola J. .

CELL REPORTS, 2018, 22 (01) :269-285

[10] SYNAPSE LOSS AND GLIOSIS IN THE MOLECULAR LAYER OF THE CEREBRAL-CORTEX IN ALZHEIMERS-DISEASE AND IN FRONTAL-LOBE DEGENERATION [J].

BRUN, A ;

LIU, XY ;

ERIKSON, C .

NEURODEGENERATION, 1995, 4 (02) :171-177

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