Lack of Detectable HIV-1-Specific CD8+ T Cell Responses in Zambian HIV-1-Exposed Seronegative Partners of HIV-1-Positive Individuals

被引：15

作者：

Addo, Marylyn M. ^{[1
,7
]}

Altfeld, Marcus ^{[1
]}

Brainard, Diana M. ^{[1
]}

Rathod, Almas ^{[1
]}

Piechocka-Trocha, Alicja ^{[1
]}

Fideli, Ulgen ^{[6
]}

Mulenga, Joseph ^{[6
]}

Shutes, Erin ^{[6
]}

Alvino, Donna Marie L. ^{[1
]}

Hunter, Eric ^{[2
,3
,4
]}

Allen, Susan A. ^{[2
,3
,6
]}

Walker, Bruce D. ^{[1
,5
]}

机构：

[1] Ragon Inst MGH Harvard & MIT, Charlestown, MA 02129 USA

[2] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[3] Emory Univ, Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[4] Emory Univ, Emory Vaccine Ctr Yerkes, Natl Primate Res Ctr, Atlanta, GA 30322 USA

[5] Howard Hughes Med Inst, Chevy Chase, MD USA

[6] Zambia Emory HIV Res Project, Rwanda Zambia HIV Res Grp, Lusaka, Zambia

[7] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 02期

基金：

美国国家卫生研究院;

关键词：

DISCORDANT COUPLES; HIV-1; INFECTION; CONCORDANT; NAIROBI; MEN;

D O I：

10.1093/infdis/jiq028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.

引用

页码：258 / 262

页数：5

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