Applications of elastin-like polypeptides in tissue engineering

被引：265
|
作者：
Nettles, Dana L. [1 ]
Chilkoti, Ashutosh [1 ]
Setton, Lori A. [1 ,2 ]
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[2] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC 27710 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 15期
关键词：
Hydrogel; Tissue engineering; Cartilage; Liver; Elastin; Crosslinking; Vascular graft; ENDOTHELIAL-CELL ADHESION; MATRIX PROTEIN FILMS; EXTRACELLULAR-MATRIX; CROSS-LINKING; IN-VITRO; ELASTOMERIC POLYPENTAPEPTIDES; MECHANICAL-PROPERTIES; PHYSICAL-PROPERTIES; STEM-CELLS; HYDROGELS;
D O I：
10.1016/j.addr.2010.04.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：1479 / 1485
页数：7
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