Applications of elastin-like polypeptides in tissue engineering

被引：270
作者：
Nettles, Dana L. [1 ]
Chilkoti, Ashutosh [1 ]
Setton, Lori A. [1 ,2 ]
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[2] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC 27710 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 15期
关键词：
Hydrogel; Tissue engineering; Cartilage; Liver; Elastin; Crosslinking; Vascular graft; ENDOTHELIAL-CELL ADHESION; MATRIX PROTEIN FILMS; EXTRACELLULAR-MATRIX; CROSS-LINKING; IN-VITRO; ELASTOMERIC POLYPENTAPEPTIDES; MECHANICAL-PROPERTIES; PHYSICAL-PROPERTIES; STEM-CELLS; HYDROGELS;
D O I：
10.1016/j.addr.2010.04.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：1479 / 1485
页数：7
相关论文
共 52 条
[1]  
Alberts B, 2002, CELL, V4, P1065
[2]   Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide [J].
Betre, H ;
Ong, SR ;
Guilak, F ;
Chilkoti, A ;
Fermor, B ;
Setton, LA .
BIOMATERIALS, 2006, 27 (01) :91-99
[3]  
Betre H, 2002, P ANN INT IEEE EMBS, P829, DOI 10.1109/IEMBS.2002.1137096
[4]   Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair [J].
Betre, H ;
Setton, LA ;
Meyer, DE ;
Chilkoti, A .
BIOMACROMOLECULES, 2002, 3 (05) :910-916
[5]  
Buckwalter J A, 1983, Instr Course Lect, V32, P349
[6]   GENETIC-ENGINEERING OF STRUCTURAL PROTEIN POLYMERS [J].
CAPPELLO, J ;
CRISSMAN, J ;
DORMAN, M ;
MIKOLAJCZAK, M ;
TEXTOR, G ;
MARQUET, M ;
FERRARI, F .
BIOTECHNOLOGY PROGRESS, 1990, 6 (03) :198-202
[7]   Engineered protein polymers for drug delivery and biomedical applications [J].
Cappello, J ;
Ghandehari, H .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (08) :1053-1055
[8]  
CAPPELLO J, 1994, ABSTR PAP AM CHEM S, V207, P82
[9]  
Dandu R, 2006, ACS SYM SER, V924, P150
[10]   Mechanical properties of artificial protein matrices engineered for control of cell and tissue behavior [J].
Di Zio, K ;
Tirrell, DA .
MACROMOLECULES, 2003, 36 (05) :1553-1558
123456