Effect of bacterial metabolism in the intestine on colorectal tumors induced by 1,2-dimethylhydrazine in transgenic mice harboring human prototype c-Ha-ras genes

被引：0

作者：

Ohno, K ^{[1
]}

Narushima, S ^{[1
]}

Takeuchi, S ^{[1
]}

Itoh, K ^{[1
]}

Itoh, T ^{[1
]}

Hioki, K ^{[1
]}

Nomura, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Vet Publ Hlth, Bunkyo Ku, Tokyo 1138657, Japan

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2001年 / 20卷 / 01期

关键词：

transgenic mice; colorectal tumors; intestinal metabolism; dymethylhydrazine; c-Ha-ras gene; apple pectin; Bifidobacterium longum;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The number of colorectal tumors per mouse induced by 1,2-dimethylhydrazine in transgenic (Tg) mice carrying human c-Ha-ras genes was significantly reduced by ingestion of apple pectin (AP) or a culture condensate of Bifidobacterium longum(MB) compared with a control diet and non-Tg mice. However, there were no differences in the composition of fecal flora, water content, beta -glucuronidase and beta -glucosidase activities, and concentrations of organic acids and putrefactive products in the feces between the AP or MB diet and the control diet, or between the Tg mice and non-Tg mice. The concentration of secondary bile acids in the MB diet group was higher than that in the control group. These results suggested that there was no relationship between prevention of colorectal tumors in Tg mice and the AP or MB diet, or improvement of the intestinal environment due to these functional foods.

引用

页码：51 / 56

页数：6