Photobiomodulation Therapy for Age-Related Macular Degeneration and Diabetic Retinopathy: A Review

被引:19
作者
Muste, Justin C. [1 ]
Russell, Matthew W. [1 ]
Singh, Rishi P. [1 ]
机构
[1] Cleveland Clin, Ctr Ophthalm Bioinformat, Cole Eye Inst, 9500 Euclid Ave,I-32, Cleveland, OH 44195 USA
关键词
photobiomodulation therapy; age-related macular degeneration; diabetic macular edema; diabetic retinopathy; INFLAMMATION; BENEFITS; LESIONS; MODEL;
D O I
10.2147/OPTH.S272327
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: Photobiomodulation therapy (PBT) has emerged as a possible treatment for age related macular degeneration (AMD) and diabetic retinopathy (DR). This review seeks to summarize the application of PBT in AMD and DR. Methods: The National Clinical Trial (NCT) database and PubMed were queried using a literature search strategy and reviewed by the authors. Results: Fourteen studies examining the application of PBT for AMD and nine studies examining the application of PBT for diabetic macular edema (DME) were extracted from 60 candidate publications. Discussion: Despite notable methodological differences between studies, PBT has been reported to treat certain DR and AMD patients. DR patients with center involving DME and VA >= 20/25 have demonstrated response to treatment. AMD patients at Age-Related Eye Disease Study Stages 2-4 with VA >= 20/200 have also shown response to treatment. Results of major clinical trials are pending. Conclusion: PBT remains an emergent therapy with possible applications in DR and AMD. Further, high powered studies monitored by a neutral party with standard devices, treatment delivery and treatment timing are needed.
引用
收藏
页码:3709 / 3720
页数:12
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