Cancer and the microbiota

被引：1024

作者：

Garrett, Wendy S. ^{[1
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机构：

[1] Harvard Univ, TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[2] Harvard Univ, TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[5] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

来源：

SCIENCE | 2015年 / 348卷 / 6230期

关键词：

ENTEROTOXIGENIC BACTEROIDES-FRAGILIS; CHAIN FATTY-ACIDS; NF-KAPPA-B; INTESTINAL INFLAMMATION; FUSOBACTERIUM-NUCLEATUM; GUT MICROBIOTA; PROTEIN AVRA; COLON; BACTERIA; ACTIVATION;

D O I：

10.1126/science.aaa4972

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A host's microbiota may increase, diminish, or have no effect at all on cancer susceptibility. Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host-microbiota interactions with environmental factors in carcinogenesis, and exploiting such knowledge for cancer diagnosis and treatment are areas of intensive interest. This Review considers how microbes and the microbiota may amplify or mitigate carcinogenesis, responsiveness to cancer therapeutics, and cancer-associated complications.

引用

页码：80 / 86

页数：7

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