Variations in clinical features and oncologic behaviors of T1 colorectal cancer according to tumor location

被引：11

作者：

Ouchi, Akira ^{[1
]}

Toriyama, Kazuhiro ^{[2
]}

Kinoshita, Takashi ^{[1
]}

Tanaka, Tsutomu ^{[3
]}

Shimizu, Yasuhiro ^{[1
]}

Niwa, Yasumasa ^{[3
]}

Tajika, Masahiro ^{[3
]}

Komori, Koji ^{[1
]}

机构：

[1] Aichi Canc Ctr Hosp, Dept Gastroenterol Surg, Chikusa Ku, 1-1 Kanokoden, Nagoya, Aichi 4648681, Japan

[2] Aichi Canc Ctr Hosp, Dept Gastroenterol, Nagoya, Aichi, Japan

[3] Aichi Canc Ctr Hosp, Dept Endoscopy, Nagoya, Aichi, Japan

来源：

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | 2020年 / 25卷 / 06期

关键词：

Colorectal neoplasms; Endoscopic mucosal resection; Lymphatic metastasis; RIGHT-SIDED COLON; CARCINOMA; PROGNOSIS; DEVELOPS; FLAT;

D O I：

10.1007/s10147-020-01642-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Different genetic characteristics according to tumor location result in variations in survival rates and treatment responses in advanced colorectal cancer (CRC). However, the effects of tumor location during early CRC are still unclear. Methods Patients with T1 CRC treated between 2003 and 2019 were enrolled from a prospectively collected database. Patients were once divided into four groups, then combined into two groups (right- and left-sided CRC) according to the tumor location, and clinical features and oncologic behaviors were compared. Results In total, 458 patients were analyzed. Right-sided CRC had a lower incidence of polypoid type tumor than left-sided CRC (36/126 (28.6%) vs 186/332 (56.0%), p < 0.001). There were no differences in tumor size, pathological grade, pT1 substage and lymphovascular invasion between right- and left-sided CRC. Overall, lymph nodal involvement was observed in 42/458 (9.1%) patients. Right-sided CRC had a lower rate of patients with lymph nodal involvement than left-sided CRC (6/126 (4.8%) vs 36/332 (10.8%), p = 0.04). Conclusion The present study revealed that there were significant differences in the macroscopic type and the incidence of lymph node involvement between right- and left-sided CRC. The clinical features and oncologic behaviors of T1 CRC are possible to vary according to tumor location.

引用

页码：1130 / 1136

页数：7

共 27 条

[1]

[Anonymous], 2009, JAP CLASS COL CARC

[2] Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials [J].

Arnold, D. ;

Lueza, B. ;

Douillard, J. -Y. ;

Peeters, M. ;

Lenz, H. -J. ;

Venook, A. ;

Heinemann, V. ;

Van Cutsem, E. ;

Pignon, J. -P. ;

Tabernero, J. ;

Cervantes, A. ;

Ciardiello, F. .

ANNALS OF ONCOLOGY, 2017, 28 (08) :1713-1729

[3] Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions [J].

De Sousa E Melo, Felipe ;

Wang, Xin ;

Jansen, Marnix ;

Fessler, Evelyn ;

Trinh, Anne ;

de Rooij, Laura P. M. H. ;

de Jong, Joan H. ;

de Boer, Onno J. ;

van Leersum, Ronald ;

Bijlsma, Maarten F. ;

Rodermond, Hans ;

van der Heijden, Maartje ;

van Noesel, Carel J. M. ;

Tuynman, Jurriaan B. ;

Dekker, Evelien ;

Markowetz, Florian ;

Medema, Jan Paul ;

Vermeulen, Louis .

NATURE MEDICINE, 2013, 19 (05) :614-618

[4] Microbiota organization is a distinct feature of proximal colorectal cancers [J].

Dejea, Christine M. ;

Wick, Elizabeth C. ;

Hechenbleikner, Elizabeth M. ;

White, James R. ;

Welch, Jessica L. Mark ;

Rossetti, Blair J. ;

Peterson, Scott N. ;

Snesrud, Erik C. ;

Borisy, Gary G. ;

Lazarev, Mark ;

Stein, Ellen ;

Vadivelu, Jamuna ;

Roslani, April C. ;

Malik, Ausuma A. ;

Wanyiri, Jane W. ;

Goh, Khean L. ;

Thevambiga, Iyadorai ;

Fu, Kai ;

Wan, Fengyi ;

Llosa, Nicolas ;

Housseau, Franck ;

Romans, Katharine ;

Wu, XinQun ;

McAllister, Florencia M. ;

Wu, Shaoguang ;

Vogelstein, Bert ;

Kinzler, Kenneth W. ;

Pardoll, Drew M. ;

Sears, Cynthia L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (51) :18321-18326

[5] A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS [J].

FEARON, ER ;

VOGELSTEIN, B .

CELL, 1990, 61 (05) :759-767

[6] Proportion of de novo cancers among colorectal cancers in Japan [J].

Goto, Hideyo ;

Oda, Yasushi ;

Murakami, Yoshitaka ;

Tanaka, Tomofumi ;

Hasuda, Kiwamu ;

Goto, Sayoko ;

Sasaki, Yutaka ;

Sakisaka, Shotaro ;

Hattori, Masahiro .

GASTROENTEROLOGY, 2006, 131 (01) :40-46

[7] Poly(C)-binding protein 1 mediates drug resistance in colorectal cancer [J].

Guo, Jiani ;

Zhu, Changli ;

Yang, Kangqun ;

Li, Jin ;

Du, Nan ;

Zong, Mingzhu ;

Zhou, Jianwei ;

He, Jingdong .

ONCOTARGET, 2017, 8 (08) :13312-13319

[8]

IKEGAMI M, 1987, ACTA PATHOL JAPON, V37, P21

[9] Classification of colorectal cancer based on correlation of clinical, morphological and molecular features [J].

Jass, J. R. .

HISTOPATHOLOGY, 2007, 50 (01) :113-130

[10] Emerging concepts in colorectal neoplasia [J].

Jass, JR ;

Whitehall, VLJ ;

Young, J ;

Leggett, BA .

GASTROENTEROLOGY, 2002, 123 (03) :862-876

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