Antitumor activity of quaternized chitosan-based electrospun implants against Graffi myeloid tumor

被引：63

作者：

Toshkova, R. ^{[2
]}

Manolova, N. ^{[1
]}

Gardeva, E. ^{[2
]}

Ignatova, M. ^{[1
]}

Yossifova, L. ^{[2
]}

Rashkov, I. ^{[1
]}

Alexandrov, M. ^{[2
]}

机构：

[1] Bulgarian Acad Sci, Inst Polymers, Lab Bioact Polymers, BG-1113 Sofia, Bulgaria

[2] Bulgarian Acad Sci, Inst Expt Pathol & Parasitol, BG-1113 Sofia, Bulgaria

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2010年 / 400卷 / 1-2期

关键词：

Antitumor activity; Chitosan; Electrospinning; Drug delivery system; Nanofibrous implants; Doxorubicin; WATER-SOLUBLE CHITOSAN; CHEMOTHERAPY; DELIVERY; FIBERS; CARCINOMA; APOPTOSIS; POLYMER; CANCER; MATS;

D O I：

10.1016/j.ijpharm.2010.08.039

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanofibrous implants containing quaternized chitosan (QCh), poly(L-lactide-co-D,L-lactide) (coPLA), and the antitumor drug doxorubicin (DOX) were fabricated by electrospinning. The surface chemical composition and the morphology of the implants were characterized by XPS and SEM. In vitro cell viability studies demonstrated that Qch- and DOX-based implants exhibited high cytotoxicity against Graffi tumor cells. The implants efficiently inhibited the growth of Graffi tumor in hamsters with minimum weight loss. Insertion of QCh/coPLA/DOX implants in the place of removed tumor led to an increase in the animal survival rate and to a decrease in the percentage of recurrences. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：221 / 233

页数：13

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