Immunotherapy Progress in Mismatch Repair-Deficient Colorectal Cancer and Future Therapeutic Challenges

被引：20

作者：

Link, James T. ^{[1
]}

Overman, Michael James ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, 1515 Holcombe Blvd,Unit 426, Houston, TX 77030 USA

来源：

CANCER JOURNAL | 2016年 / 22卷 / 03期

关键词：

Colorectal cancer; immune checkpoint; microsatellite instability; mismatch repair deficiency; ACTIVE SPECIFIC IMMUNOTHERAPY; COLON-CANCER; MICROSATELLITE INSTABILITY; PD-1; BLOCKADE; STAGE-II; TUMORS; ANTIBODY; SAFETY; LOCATION; VACCINE;

D O I：

10.1097/PPO.0000000000000196

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Initial investigations of immune-checkpoint therapy targeting Programmed cell death protein 1/programed death ligand 1 in unselected colorectal cancer (CRC) has shown limited to no activity. However, a subset of CRC, characterized by mismatch deficiency or microsatellite instability high (MSI-high), has shown robust early signals of antitumor activity with PD1 targeting. It is now clear that MSI-high CRC represents a unique-molecular and immunological tumor subset. Further study and understanding of the immunological microenvironment of these tumors will be critical to continued success with immune-based approaches in MSI-high CRC. This review discusses the current biological understanding of MSI-high CRC and outlines the current and ongoing clinical trials investigating immunotherapy.

引用

页码：190 / 195

页数：6

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