Acyclic nucleoside phosphonates in the chemotherapy of DNA virus and retrovirus infections

被引：62

作者：

De Clercq, E ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

INTERVIROLOGY | 1997年 / 40卷 / 5-6期

关键词：

acyclic nucleoside phosphonates; HPMPC (cidofovir); PMEA (adefovir); PMPA;

D O I：

10.1159/000150563

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The acyclic nucleoside phosphonates [HPMPC (cidofovir), PMEA (adefovir) and PMPA] have proved to be effective in vitro (cell culture systems) and in vivo (animal models, clinical studies) against a wide variety of DNA virus and retrovirus infections: i.e., HPMPC against herpesvirus (herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, human herpesvirus types 6, 7, and 18), polyoma-, papilloma-, adeno-, and poxvirus (vaccinia virus, molluscum contagiosum virus) infections; PMEA against herpesvirus, hepadnavirus (human hepatitis B virus) and retrovirus (human immunodeficiency virus type 1 and 2, simian immunodeficiency virus, and feline immunodeficiency virus) infections; and PMPA against both hepadna- and retrovirus infections.

引用

页码：295 / 303

页数：9

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