Cage complexes of transition metals in biochemistry and medicine

被引：33
作者：
Voloshin, Ya. Z.
Varzatskii, O. A.
Bubnov, Yu. N.
机构：
[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Compounds, Moscow 119991, Russia
[2] L Ya Karpov Res Physicochem Inst, Moscow 105064, Russia
[3] Natl Acad Sci Ukraine, VI Vernadsky Inst Gen & Chem, UA-03680 Kiev, Ukraine
来源：
RUSSIAN CHEMICAL BULLETIN | 2007年 / 56卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
macrocycles; clathrochelates; radiotherapy; HIV therapy; antioxidants; phenols; membrane transport; closo-borates; boron neutron capture therapy; encapsulation; nucleic acids; detergents; magnetic resonance imaging; adamantane and its derivatives;
D O I：
10.1007/s11172-007-0100-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The review presents the following main trends and the perspectives of application of the transition metal clathrochelates in medicine and biochemistry: encapsulation of radioactive metal ion for diagnostics and therapy; imaging agents for MRI; antidotes and prolonged pharmaceuticals; pharmaceuticals for boron neutron capture therapy; antihelminthic and antiparasitic detergents; antioxidants; membrane transport of the metal ions; interaction of the cage metal complexes with nucleic acids and the potential of their self-assembling reactions in immunology and molecular biology (recognition of antibodies, antigens and DNA sites); design of HIV inhibitors for the therapy.
引用
收藏
页码：577 / 605
页数：29
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