Do the different parental 'heteromes' cause genomic shock in newly formed allopolyploids?

被引:110
作者
Comai, L [1 ]
Madlung, A [1 ]
Josefsson, C [1 ]
Tyagi, A [1 ]
机构
[1] Univ Washington, Dept Biol, Seattle, WA 98195 USA
关键词
genome stability; hybridization; polyploidy; DNA methylation;
D O I
10.1098/rstb.2003.1305
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Allopolyploidy, the joining of two parental genomes in a polyploid organism with diploid meiosis, is an important mechanism of reticulate evolution. While many successful long-established allopolyploids are known, those formed recently undergo an instability phase whose basis is now being characterized. We describe observations made with the Arabidopsis system that include phenotypic instability, gene silencing and activation, and methylation changes. We present a model based on the epigenetic destabilization of genomic repeats, which in the parents are heterochromatinized and suppressed. We hypothesize that loss of epigenetic suppression of these sequences, here defined as the heterome, results in genomic instability including silencing of single-copy genes.
引用
收藏
页码:1149 / 1155
页数:7
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