Cerebral dynamics and metabolism of hyperpolarized [1-13C]pyruvate using time-resolved MR spectroscopic imaging

被引：50

作者：

Hurd, Ralph E. ^{[1
]}

Yen, Yi-Fen ^{[1
]}

Tropp, James ^{[1
]}

Pfefferbaum, Adolf ^{[2
]}

Spielman, Daniel M. ^{[3
]}

Mayer, Dirk ^{[2
,3
]}

机构：

[1] GE Healthcare, Global Appl Sci Lab, Menlo Pk, CA 94025 USA

[2] SRI Int, Neurosci Program, Menlo Pk, CA 94025 USA

[3] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2010年 / 30卷 / 10期

关键词：

blood-brain transport; cerebral blood volume; hyperpolarized-C-13; lactate; pyruvate; rat brain; LACTATE; TRANSPORT; PYRUVATE; CONSTANTS;

D O I：

10.1038/jcbfm.2010.93

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dynamic hyperpolarized [1-C-13] pyruvate metabolic imaging in the normal anesthetized rat brain is demonstrated on a clinical 3-T magnetic resonance imaging scanner. A 12-second bolus injection of hyperpolarized [1-C-13] pyruvate is imaged at a 3-second temporal resolution. The observed dynamics are evaluated with regard to cerebral blood volume (CBV), flow, transport, and metabolic exchange with the cerebral lactate pool. A model for brain [1-C-13] lactate, based on blood-brain transport kinetics, CBV, and the observed pyruvate dynamics is described. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1734-1741; doi:10.1038/jcbfm.2010.93; published online 30 June 2010

引用

页码：1734 / 1741

页数：8

共 23 条

[1] Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading [J].

Albers, Mark J. ;

Bok, Robert ;

Chen, Albert P. ;

Cunningham, Charles H. ;

Zierhut, Matt L. ;

Zhang, Vickie Yi ;

Kohler, Susan J. ;

Tropp, James ;

Hurd, Ralph E. ;

Yen, Yi-Fen ;

Nelson, Sarah J. ;

Vigneron, Daniel B. ;

Kurhanewicz, John .

CANCER RESEARCH, 2008, 68 (20) :8607-8615

[2] Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies [J].

Chen, Albert P. ;

Kurhanewicz, John ;

Bok, Robert ;

Xu, Duan ;

Joun, David ;

Zhang, Vickie ;

Nelson, Sarah J. ;

Hurd, Ralph E. ;

Vigneron, Daniel B. .

MAGNETIC RESONANCE IMAGING, 2008, 26 (06) :721-726

[3] Hyperpolarized c-13 spectroscopic imaging of the TRAMP mouse at 3T - Initial experience [J].

Chen, Albert P. ;

Albers, Mark J. ;

Cunningham, Charles H. ;

Kohler, Susan J. ;

Yen, Yi-Fen ;

Hurd, Ralph E. ;

Tropp, James ;

Bok, Robert ;

Pauly, John M. ;

Nelson, Sarah J. ;

Kurhanewicz, John ;

Vigneron, Daniel B. .

MAGNETIC RESONANCE IN MEDICINE, 2007, 58 (06) :1099-1106

[4]

CHEN AP, 2008, P 16 ANN M ISMRM TOR, P888

[5]

Chronik B, 2000, MAGN RESON MATER PHY, V10, P131

[6] KINETICS OF BLOOD-BRAIN-BARRIER TRANSPORT OF PYRUVATE, LACTATE AND GLUCOSE IN SUCKLING, WEANLING AND ADULT-RATS [J].

CREMER, JE ;

CUNNINGHAM, VJ ;

PARDRIDGE, WM ;

BRAUN, LD ;

OLDENDORF, WH .

JOURNAL OF NEUROCHEMISTRY, 1979, 33 (02) :439-445

[7] Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy [J].

Day, Sam E. ;

Kettunen, Mikko I. ;

Gallagher, Ferdia A. ;

Hu, De-En ;

Lerche, Mathilde ;

Wolber, Jan ;

Golman, Klaes ;

Ardenkjaer-Larsen, Jan Henrik ;

Brindle, Kevin M. .

NATURE MEDICINE, 2007, 13 (11) :1382-1387

[8] Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI [J].

Golman, Klaes ;

Petersson, J. Stefan ;

Magnusson, Peter ;

Johansson, Edvin ;

Akeson, Per ;

Chai, Chun-Ming ;

Hansson, Georg ;

Mansson, Sven .

MAGNETIC RESONANCE IN MEDICINE, 2008, 59 (05) :1005-1013

[9] Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis [J].

Golman, Klaes ;

in't Zandt, Rene ;

Lerche, Mathilde ;

Pehrson, Rikard ;

Ardenkjaer-Larsen, Jan Henrik .

CANCER RESEARCH, 2006, 66 (22) :10855-10860

[10] Metabolic Imaging in the Anesthetized Rat Brain Using Hyperpolarized [1-13C] Pyruvate and [1-13C] Ethyl Pyruvate [J].

Hurd, Ralph E. ;

Yen, Yi-Fen ;

Mayer, Dirk ;

Chen, Albert ;

Wilson, David ;

Kohler, Susan ;

Bok, Robert ;

Vigneron, Daniel ;

Kurhanewicz, John ;

Tropp, James ;

Spielman, Daniel ;

Pfefferbaum, Adolf .

MAGNETIC RESONANCE IN MEDICINE, 2010, 63 (05) :1137-1143

← 1 2 3 →