99mTc DPD Is the Preferential Bone Tracer for Diagnosis of Cardiac Transthyretin Amyloidosis

被引：8

作者：

Rossi, Pascal ^{[2
]}

Tessonnier, Laurent ^{[1
]}

Frances, Yves ^{[2
]}

Mundler, Olivier ^{[1
]}

Granel, Brigitte ^{[2
]}

机构：

[1] North Hosp, Dept Nucl Med, Publ Hosp Marseilles, Marseille 20, France

[2] North Hosp, Dept Internal Med, Publ Hosp Marseilles, Marseille 20, France

来源：

CLINICAL NUCLEAR MEDICINE | 2012年 / 37卷 / 08期

关键词：

cardiac amyloidosis; DPD; bone scan; SCINTIGRAPHY; FEATURES; HEART;

D O I：

10.1097/RLU.0b013e318248512c

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We emphasize the role of Tc-99m-3,3-diphosphono-1,2-propanodicarboxylicacid (DPD) scintigraphy as a noninvasive tool to distinguish transthyretin (TTR)-related cardiac amyloidosis from other forms of cardiac amyloidosis. We report the case of a 76-year-old male patient suffering from congestive heart failure in whom imaging investigation by DPD scintigraphy showed a strong cardiac uptake highly suggestive of TTR amyloidosis variant. TTR-related cardiac amyloidosis was confirmed on myocardial biopsies by immunohistochemistry analysis. This case supports the growing interest in DPD scintigraphy for typing cardiac amyloidosis and for its contribution in the place of invasive myocardial biopsy. © 2012 Lippincott Williams & Wilkins, Inc.

引用

页码：E209 / E210

页数：2

共 12 条

[1] The hereditary amyloidoses [J].

Benson, MD .

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2003, 17 (06) :909-927

[2] Cardiac amyloidosis in African Americans: Comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis [J].

Connors, Lawreen H. ;

Prokaeva, Tatiana ;

Lim, Amareth ;

Theberge, Roger ;

Falk, Rodney H. ;

Doros, Gheorghe ;

Berg, Alan ;

Costello, Catherine E. ;

O'Hara, Carl ;

Seldin, David C. ;

Skinner, Martha .

AMERICAN HEART JOURNAL, 2009, 158 (04) :607-614

[3] The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement [J].

Dubrey, SW ;

Cha, K ;

Anderson, J ;

Chamarthi, B ;

Reisinger, J ;

Skinner, M ;

Falk, RH .

QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, 1998, 91 (02) :141-157

[4] Diagnosis and management of the cardiac amyloidoses [J].

Falk, RH .

CIRCULATION, 2005, 112 (13) :2047-2060

[5] Nuclear imaging in cardiac amyloidosis [J].

Glaudemans, A. W. J. M. ;

Slart, R. H. J. A. ;

Zeebregts, C. J. ;

Veltman, N. C. ;

Tio, R. A. ;

Hazenberg, B. P. C. ;

Dierckx, R. A. J. O. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2009, 36 (04) :702-714

[6] Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis. [J].

Lachmann, HJ ;

Booth, DR ;

Booth, SE ;

Bybee, A ;

Gilbertson, JA ;

Gillmore, JD ;

Pepys, MB ;

Hawkins, PN .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (23) :1786-1791

[7] Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy [J].

Perugini, E ;

Guidalotti, PL ;

Salvi, F ;

Cooke, RMT ;

Pettinato, C ;

Riva, L ;

Leone, O ;

Farsad, M ;

Ciliberti, P ;

Bacchi-Reggiani, L ;

Fallani, F ;

Branzi, A ;

Rapezzi, C .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 46 (06) :1076-1084

[8] 99mTc-DPD scintigraphy in transthyretin-related familial amyloidotic polyneuropathy [J].

Puille, M ;

Altland, K ;

Linke, RP ;

Steen-Müller, MK ;

Klett, R ;

Steiner, D ;

Bauer, R .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2002, 29 (03) :376-379

[9] Role of 99mTc-DPD Scintigraphy in Diagnosis and Prognosis of Hereditary Transthyretin-Related Cardiac Amyloidosis [J].

Rapezzi, Claudio ;

Quarta, Candida C. ;

Guidalotti, Pier Luigi ;

Pettinato, Cinzia ;

Fanti, Stefano ;

Leone, Ornella ;

Ferlini, Alessandra ;

Longhi, Simone ;

Lorenzini, Massimiliano ;

Reggiani, Letizia Bacchi ;

Gagliardi, Christian ;

Gallo, Pamela ;

Villani, Caterina ;

Salvi, Fabrizio .

JACC-CARDIOVASCULAR IMAGING, 2011, 4 (06) :659-670

[10] Usefulness and limitations of 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy in the aetiological diagnosis of amyloidotic cardiomyopathy [J].

Rapezzi, Claudio ;

Quarta, Candida Cristina ;

Guidalotti, Pier Luigi ;

Longhi, Simone ;

Pettinato, Cinzia ;

Leone, Ornella ;

Ferlini, Alessandra ;

Salvi, Fabrizio ;

Gallo, Pamela ;

Gagliardi, Christian ;

Branzi, Angelo .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2011, 38 (03) :470-478

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