Unravelling the adiponectin paradox: novel roles of adiponectin in the regulation of cardiovascular disease

被引：115

作者：

Woodward, Lavinia ^{[1
]}

Akoumianakis, Ioannis ^{[1
]}

Antoniades, Charalambos ^{[1
]}

机构：

[1] Univ Oxford, Radcliffe Dept Med, Cardiovasc Med Div, Oxford, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2017年 / 174卷 / 22期

关键词：

CORONARY-HEART-DISEASE; EPICARDIAL ADIPOSE-TISSUE; NITRIC-OXIDE SYNTHASE; ACTIVATED PROTEIN-KINASE; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; OXIDATIVE STRESS; PLASMA ADIPONECTIN; CIRCULATING ADIPONECTIN;

D O I：

10.1111/bph.13619

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adipose tissue (AT) has recently been identified as a dynamic endocrine organ secreting a wide range of adipokines. Adiponectin is one such hormone, exerting endocrine and paracrine effects on the cardiovascular system. At a cellular and molecular level, adiponectin has anti-inflammatory, antioxidant and anti-apoptotic roles, thereby mitigating key mechanisms underlying cardiovascular disease (CVD) pathogenesis. However, adiponectin expression in human AT as well as its circulating levels are increased in advanced CVD states, and it is actually considered by many as a 'rescue hormone'. Due to the complex mechanisms regulating adiponectin's biosynthesis in the human AT, measurement of its levels as a biomarker in CVD is highly controversial, given that adiponectin exerts protective effects on the cardiovascular system but at the same time its increased levels flag advanced CVD. In this review article, we present the involvement of adiponectin in CVD pathogenesis and we discuss its role as a clinical biomarker.

引用

页码：4007 / 4020

页数：14

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