The Effects of Prenatal Alcohol Exposure on the Developmental Retina of Mice

被引：8
|
作者：
Deng, Jie-Xin [1 ]
Liu, Xi [1 ,2 ]
Zang, Jian-Feng [1 ]
Huang, Hong-En [3 ]
Xi, Yan [1 ]
Zheng, Hong [1 ]
Yao, Huan-Ling [1 ]
Yu, Dong-Ming [1 ]
Deng, Jin-Bo [1 ]
机构：
[1] Henan Univ, Coll Nursing, Inst Neurobiol, Kaifeng 475004, Henan Province, Peoples R China
[2] Henan Univ, Huaihe Hosp, Dept Ophthalmol, Kaifeng 475004, Henan Province, Peoples R China
[3] Jiujiang Hosp Tradit Med, Jiujiang 332000, Peoples R China
来源：
ALCOHOL AND ALCOHOLISM | 2012年 / 47卷 / 04期
基金：
中国国家自然科学基金;
关键词：
POSTNATAL EXPOSURE; VISUAL-CORTEX; ETHANOL; CELL; EXPRESSION; MORPHOLOGY; DAMAGE;
D O I：
10.1093/alcalc/ags025
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Aims: Our aim is to investigate the effects of prenatal alcohol exposure (PAE) on the development of retinal bipolar and horizontal cells. Methods: The alterations of the retinal bipolar and horizontal cells in P7, P14 and P30 mice were observed after PAE, with immunofluorescent labeling and DiI diolistic assay. Results: The retinal development of filial pups was affected by PAE in a dose-dependent and long-term manner. The number of bipolar cells of alcohol groups was significantly lower than that of the control, and the dendritic receptive field of horizontal cells was also significantly smaller than those of the control groups (P < 0.01). Conclusion: PAE was able to cause retarded development of pup retinal neural cells.
引用
收藏
页码：380 / 385
页数：6
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