An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JS']JSP-1 inhibitors

被引：26

作者：

Kamila, Sukanta ^{[1
]}

Ankati, Haribabu ^{[1
]}

Biehl, Edward R. ^{[1
]}

机构：

[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 34期

关键词：

3-Phenyl-2-thioxothiazolidin-4-one; 2-(1H-Indol-3-yl)-2-oxoacetaldehyde; Acid chloride; HSnBu(3); MW irradiation; AGENTS; INDOLE;

D O I：

10.1016/j.tetlet.2011.05.114

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one (7a-q) derivatives have been synthesized by the condensation reaction of 3-phenyl-2-thioxothiazolidin-4-ones (3a-h) with suitably substituted 2-(1H-indo1-3-yl)-2-oxoacetaldehyde (6a-d) under microwave condition. The thioxo-thiazolidine-4-ones were prepared from the corresponding aromatic amines (la-e) and di-(carboxy-methyl)-trithiocarbonyl (2). The aldehydes (6a-h) were synthesized from the corresponding acid chlorides (5a-d) using HSnBu(3). (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4375 / 4377

页数：3

共 28 条

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