Roles of lncRNAs in cancer: Focusing on angiogenesis

被引：64
作者：
Jin, Ke-Tao [1 ]
Yao, Jia-Yu [2 ,3 ]
Fang, Xing-Liang [4 ]
Di, Hua [2 ,5 ]
Ma, Ying-Yu [2 ,3 ]
机构：
[1] Zhejiang Univ, Shaoxing Peoples Hosp, Dept Colorectal Surg, Shaoxing Hosp,Sch Med, Shaoxing 312000, Zhejiang, Peoples R China
[2] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Key Lab Gastroenterol Zhejiang Prov, 158 Shangtang Rd, Hangzhou 310014, Zhejiang, Peoples R China
[3] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Clin Res Inst, Hangzhou 310014, Zhejiang, Peoples R China
[4] Shaoxing Univ, Shaoxing Municipal Hosp, Affiliated Hosp, Dept Hepatobiliary Surg, Shaoxing 312000, Zhejiang, Peoples R China
[5] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Acupuncture & Tuina Clin, 158 Shangtang Rd, Hangzhou 310014, Zhejiang, Peoples R China
来源：
LIFE SCIENCES | 2020年 / 252卷
基金：
中国国家自然科学基金;
关键词：
Long non-coding RNAs (lncRNAs); Cancer; Metastasis; Angiogenesis; Tumor microenvironment; LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; PROMOTES CELL-PROLIFERATION; TUMOR-GROWTH; STEM-CELLS; VASCULOGENIC MIMICRY; GLIOMA ANGIOGENESIS; ENDOTHELIAL-CELLS; SIGNALING PATHWAY; PROSTATE-CANCER;
D O I：
10.1016/j.lfs.2020.117647
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Approximately 98% of the human genome consists of non-coding sequences that are classified into two classes by size: small non-coding RNAs (<= 200 nucleotides) and long non-coding RNAs (>= 200 nucleotides). Long non-coding RNAs (lncRNAs) are involved in various cellular events and act as guides, signals, decoys, and dynamic scaffolds. Due to their oncogenic and tumor suppressive roles, lncRNAs are important in cancer development and growth. LncRNAs play their roles by modulating cancer hallmarks, including DNA damage, metastasis, immune escape, cell stemness, drug resistance, metabolic reprogramming, and angiogenesis. Angiogenesis is vital for solid tumors which guarantees their growth beyond 2 mm(3). Tumor angiogenesis is a complex process and is regulated through interaction between pro-angiogenic and anti-angiogenic factors within the tumor microenvironment. There are accumulating evidence that different lncRNAs regulate tumor angiogenesis. In this paper, we described the functions and mechanisms of lncRNAs in tumor angiogenesis.
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页数：9
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