Changes in gene expression of Zif, c-fos and cyclooxygenase-2 associated with spinal long-term potentiation

被引：8

作者：

Gjerstad, J ^{[1
]}

Lien, GF ^{[1
]}

Pedersen, LM ^{[1
]}

Valen, EC ^{[1
]}

Mollerup, S ^{[1
]}

机构：

[1] Natl Inst Occupat Hlth, N-0033 Oslo, Norway

来源：

NEUROREPORT | 2005年 / 16卷 / 13期

关键词：

c-fos; central sensitization; cyclooxygenase-2; dorsal horn; Egr-I; long-term potentiation; NGFI-A; Krox; 24; Zif/268;

D O I：

10.1097/01.wnr.0000177004.19946.12

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spinal cord long-term potentiation is often studied as a model for cellular memory of nociceptive information. In the present report, extracellular single-unit recordings and quantitative real-time reverse transcriptase polymerase chain reaction were used to examine whether the induction of spinal cord long-term potentiation involves changes in expression of Zif, c-fos and cyclooxygenase-2. The data demonstrated that induction of spinal cord long-term potentiation was associated with a transient increase in the expression of Zif at 120 min (p<0.05, long-term potentiation group vs. control group). In contrast, a decrease or no changes were observed in the expression of c-fos and cyclooxygenase-2. The transient increase of the expression of Zif is consistent with an involvement in the transition from the early to the late-phase of spinal cord long-term potentiation.

引用

页码：1477 / 1481

页数：5

共 24 条

[1] Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity [J].