Future treatment for asthma

被引：12

作者：

Charriot, Jeremy ^{[1
]}

Vachier, Isabelle ^{[1
]}

Halimi, Laurence ^{[1
]}

Gamez, Anne-Sophie ^{[1
]}

Boissin, Clement ^{[1
]}

Salama, Marine ^{[1
]}

Cucu-Jarjour, Alina ^{[1
]}

Ahmed, Engi ^{[1
]}

Bourdin, Arnaud ^{[1
,2
]}

机构：

[1] CHU Montpellier, Dept Resp Dis, Montpellier, France

[2] Univ Montpellier, Hop Arnaud de Villeneuve, PhyMedExp, INSERM,U1046,CNRS,UMR 9214, Montpellier, France

来源：

EUROPEAN RESPIRATORY REVIEW | 2016年 / 25卷 / 139期

关键词：

ENVIRONMENTAL TOBACCO-SMOKE; LONG-TERM SAFETY; DOUBLE-BLIND; INHALED CORTICOSTEROIDS; BRONCHIAL THERMOPLASTY; LUNG-FUNCTION; ANTI-IGE; INTRANASAL CORTICOSTEROIDS; 5-LIPOXYGENASE INHIBITOR; AIRWAY INFLAMMATION;

D O I：

10.1183/16000617.0069-2015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The landscape of asthma has considerably changed after 40 years of inhaled corticosteroid development and nearly 20 years since the first monoclonal antibodies (mAbs) were approved. New members of pharmacological families and more effective drug-delivery devices have been designed but the proportion of uncontrolled patients, unfortunately, remains stable. The most promising treatments now rely on targeted therapies that encourage the improvement of the characterisation of our patients. These clinical (phenotype) or new biological (endotype) tools lead to palpable personalised medicine. This review examines not only the future of mAbs and other new ways of treating asthma but also describes futuristic views based on the paradigm shifts that are ready to occur.

引用

页码：77 / 92

页数：16

共 141 条

[71] Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy [J].

Kerstjens, Huib A. M. ;

Engel, Michael ;

Dahl, Ronald ;

Paggiaro, Pierluigi ;

Beck, Ekkehard ;

Vandewalker, Mark ;

Sigmund, Ralf ;

Seibold, Wolfgang ;

Moroni-Zentgraf, Petra ;

Bateman, Eric D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (13) :1198-1207

[72] The many paths to asthma: phenotype shaped by innate and adaptive immunity [J].

Kim, Hye Young ;

DeKruyff, Rosemarie H. ;

Umetsu, Dale T. .

NATURE IMMUNOLOGY, 2010, 11 (07) :577-584

[73] Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome [J].

Kim, Sophia ;

Marigowda, Gautham ;

Oren, Eyal ;

Israel, Elliot ;

Wechsler, Michael E. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (06) :1336-1343

[74] Treatment of established asthma in a murine model using CpG oligodeoxynucleotides [J].

Kline, JN ;

Kitagaki, K ;

Businga, TR ;

Jain, VV .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2002, 283 (01) :L170-L179

[75] Genetic testing for asthma [J].

Koppelman, G. H. ;

Meerman, G. J. te ;

Postma, D. S. .

EUROPEAN RESPIRATORY JOURNAL, 2008, 32 (03) :775-782

[76] Cutting Edge: Maresin-1 Engages Regulatory T Cells To Limit Type 2 Innate Lymphoid Cell Activation and Promote Resolution of Lung Inflammation [J].

Krishnamoorthy, Nandini ;

Burkett, Patrick R. ;

Dalli, Jesmond ;

Abdulnour, Raja-Elie E. ;

Colas, Romain ;

Ramon, Sesquile ;

Phipps, Richard P. ;

Petasis, Nicos A. ;

Kuchroo, Vijay K. ;

Serhan, Charles N. ;

Levy, Bruce D. .

JOURNAL OF IMMUNOLOGY, 2015, 194 (03) :863-867

[77] Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme [J].

Krug, Norbert ;

Hohlfeld, Jens M. ;

Kirsten, Anne-Marie ;

Kornmann, Oliver ;

Beeh, Kai M. ;

Kappeler, Dominik ;

Korn, Stephanie ;

Ignatenko, Stanislav ;

Timmer, Wolfgang ;

Rogon, Cordelia ;

Zeitvogel, Jana ;

Zhang, Nan ;

Bille, Joachim ;

Homburg, Ursula ;

Turowska, Agnieszka ;

Bachert, Claus ;

Werfel, Thomas ;

Buhl, Roland ;

Renz, Jonas ;

Garn, Holger ;

Renz, Harald .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (21) :1987-1995

[78] IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction [J].

Kudo, Makoto ;

Melton, Andrew C. ;

Chen, Chun ;

Engler, Mary B. ;

Huang, Katherine E. ;

Ren, Xin ;

Wang, Yanli ;

Bernstein, Xin ;

Li, John T. ;

Atabai, Kamran ;

Huang, Xiaozhu ;

Sheppard, Dean .

NATURE MEDICINE, 2012, 18 (04) :547-554

[79] Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma [J].

Kuperman, DA ;

Huang, XZ ;

Koth, LL ;

Chang, GH ;

Dolganov, GM ;

Zhu, Z ;

Elias, JA ;

Sheppard, D ;

Erle, DJ .

NATURE MEDICINE, 2002, 8 (08) :885-889

[80] CD14 polymorphisms, microbial exposure and allergic diseases: a systematic review of gene-environment interactions [J].

Lau, M. Y. Z. ;

Dharmage, S. C. ;

Burgess, J. A. ;

Lowe, A. J. ;

Lodge, C. J. ;

Campbell, B. ;

Matheson, M. C. .

ALLERGY, 2014, 69 (11) :1440-1453

← 3 4 5 6 7 8 9 10 11 12 →