Future treatment for asthma

被引：12

作者：

Charriot, Jeremy ^{[1
]}

Vachier, Isabelle ^{[1
]}

Halimi, Laurence ^{[1
]}

Gamez, Anne-Sophie ^{[1
]}

Boissin, Clement ^{[1
]}

Salama, Marine ^{[1
]}

Cucu-Jarjour, Alina ^{[1
]}

Ahmed, Engi ^{[1
]}

Bourdin, Arnaud ^{[1
,2
]}

机构：

[1] CHU Montpellier, Dept Resp Dis, Montpellier, France

[2] Univ Montpellier, Hop Arnaud de Villeneuve, PhyMedExp, INSERM,U1046,CNRS,UMR 9214, Montpellier, France

来源：

EUROPEAN RESPIRATORY REVIEW | 2016年 / 25卷 / 139期

关键词：

ENVIRONMENTAL TOBACCO-SMOKE; LONG-TERM SAFETY; DOUBLE-BLIND; INHALED CORTICOSTEROIDS; BRONCHIAL THERMOPLASTY; LUNG-FUNCTION; ANTI-IGE; INTRANASAL CORTICOSTEROIDS; 5-LIPOXYGENASE INHIBITOR; AIRWAY INFLAMMATION;

D O I：

10.1183/16000617.0069-2015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The landscape of asthma has considerably changed after 40 years of inhaled corticosteroid development and nearly 20 years since the first monoclonal antibodies (mAbs) were approved. New members of pharmacological families and more effective drug-delivery devices have been designed but the proportion of uncontrolled patients, unfortunately, remains stable. The most promising treatments now rely on targeted therapies that encourage the improvement of the characterisation of our patients. These clinical (phenotype) or new biological (endotype) tools lead to palpable personalised medicine. This review examines not only the future of mAbs and other new ways of treating asthma but also describes futuristic views based on the paradigm shifts that are ready to occur.

引用

页码：77 / 92

页数：16

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