BRCA1 regulates caveolin-1 expression and inhibits cell invasiveness

被引：17
|
作者：
Wang, Yang
Yu, Jing
Zhan, Qimin
机构：
[1] Chinese Acad Med Sci, State Key Lab Mol Oncol, Inst Canc, Beijing 100021, Peoples R China
[2] Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China
[3] Peking Union Med Coll, Beijing 100021, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 370卷 / 02期
基金：
中国国家自然科学基金;
关键词：
BRCA1; caveolin-1; invasiveness; gene expression; translocation;
D O I：
10.1016/j.bbrc.2008.03.031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
BRCA1 is involved in multiple biological processes including DNA damage repair, cell growth, apoptosis, and transcriptional activation. Also, BRCA1 plays key roles in inhibiting cancer progression. Caveolin-1 is identified as a tumor suppressor and regulates the invasiveness of cells. However, the interactions between BRCA1 and caveolin-1 remain largely unknown. We have investigated the potential function of BRCA1 in regulation of caveolin-1 gene expression and its subcellular localization as well. The observations from RT-PCR, transfection, RNAi, and luciferase assays implied that BRCA1 could elevate caveolin-1 mRNA levels via transactivation of the caveolin-1 promoter region. Additionally, immunofluorescent approach showed that BRCA1 might inhibit the invasiveness and metastatic abilities of mammalian cells by inducing the redistribution of caveolin-1 from the cytoplasm to the cell membrane. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：201 / 206
页数：6
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