Mitochondria in innate immunity

被引：199
作者：
Arnoult, Damien [2 ]
Soares, Fraser [1 ]
Tattoli, Ivan [1 ]
Girardin, Stephen E. [1 ]
机构：
[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada
[2] Hop Paul Brousse, INSERM, U1014, F-94807 Villejuif, France
来源：
EMBO REPORTS | 2011年 / 12卷 / 09期
关键词：
mitochondria; innate immunity; MAVS; pathogen; host metabolism; NLRP3 INFLAMMASOME ACTIVATION; NF-KAPPA-B; RIG-I; ADAPTER PROTEIN; RECEPTOR; MAVS; RECOGNITION; AUTOPHAGY; RESPONSES; NLRX1;
D O I：
10.1038/embor.2011.157
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 and IRGM have been functionally associated with mitochondria. Furthermore, mitochondrial alarmins-such as mitochondrial DNA and formyl peptides-can be released by damaged mitochondria and trigger inflammation. Therefore, mitochondria emerge as a fundamental hub for innate immune signalling.
引用
收藏
页码：901 / 910
页数：10
相关论文
共 70 条
  • [1] Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1
    Abdul-Sater, Ali A.
    Said-Sadier, Najwane
    Lam, Verissa M.
    Singh, Bhavni
    Pettengill, Matthew A.
    Soares, Fraser
    Tattoli, Ivan
    Lipinski, Simone
    Girardin, Stephen E.
    Rosenstiel, Philip
    Ojcius, David M.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (53) : 41637 - 41645
  • [2] Toll-like receptor signalling
    Akira, S
    Takeda, K
    [J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) : 499 - 511
  • [3] The role of mitochondria in cellular defense against microbial infection
    Arnoult, Damien
    Carneiro, Leticia
    Tattoli, Ivan
    Girardin, Stephen E.
    [J]. SEMINARS IN IMMUNOLOGY, 2009, 21 (04) : 223 - 232
  • [4] An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix
    Arnoult, Damien
    Soares, Fraser
    Tattoli, Ivan
    Castanier, Celine
    Philpott, Dana J.
    Girardin, Stephen E.
    [J]. JOURNAL OF CELL SCIENCE, 2009, 122 (17) : 3161 - 3168
  • [5] Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses
    Barber, Glen N.
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (01) : 10 - 20
  • [6] The microbial and danger signals that activate Nod-like receptors
    Benko, Szilvia
    Philpott, Dana J.
    Girardin, Stephen E.
    [J]. CYTOKINE, 2008, 43 (03) : 368 - 373
  • [7] Shigella Induces Mitochondrial Dysfunction and Cell Death in Nonmyleoid Cells
    Carneiro, Leticia A. M.
    Travassos, Leonardo H.
    Soares, Fraser
    Tattoli, Ivan
    Magalhaes, Joao G.
    Bozza, Marcelo T.
    Plotkowski, Maria C.
    Sansonetti, Philippe J.
    Molkentin, Jeffery D.
    Philpott, Dana J.
    Girardin, Stephen E.
    [J]. CELL HOST & MICROBE, 2009, 5 (02) : 123 - 136
  • [8] Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway
    Castanier, Celine
    Garcin, Dominique
    Vazquez, Aime
    Arnoult, Damien
    [J]. EMBO REPORTS, 2010, 11 (02) : 133 - 138
  • [9] Mitochondria: Dynamic organelles in disease, aging, and development
    Chan, David C.
    [J]. CELL, 2006, 125 (07) : 1241 - 1252
  • [10] HIF-1α is essential for myeloid cell-mediated inflammation
    Cramer, T
    Yamanishi, Y
    Clausen, BE
    Förster, I
    Pawlinski, R
    Mackman, N
    Haase, VH
    Jaenisch, R
    Corr, M
    Nizet, V
    Firestein, GS
    Gerber, HP
    Ferrara, N
    Johnson, RS
    [J]. CELL, 2003, 112 (05) : 645 - 657
1234567