Polymer vectors via controlled/living radical polymerization for gene delivery

被引：150

作者：

Xu, F. J. ^{[1
]}

Yang, W. T. ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Coll Mat Sci & Engn, State Key Lab Chem Resource Engn, Key Lab Carbon Fiber & Funct Polymers,Minist Educ, Beijing 100029, Peoples R China

来源：

PROGRESS IN POLYMER SCIENCE | 2011年 / 36卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Gene delivery; Polymeric carriers; LRP; ATRP; RAFT; FRAGMENTATION CHAIN-TRANSFER; HYDROXYPROPYL CELLULOSE BACKBONES; BIOCOMPATIBLE BLOCK-COPOLYMERS; AQUEOUS RAFT POLYMERIZATION; METHYL-ETHER METHACRYLATE; REVERSIBLE ADDITION; IN-VITRO; 2-(DIMETHYLAMINO)ETHYL METHACRYLATE; STAR POLYMERS; TRIBLOCK COPOLYMERS;

D O I：

10.1016/j.progpolymsci.2010.11.005

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The design of efficient gene delivery vectors is a challenging task in gene therapy. Recent progress in living/controlled radical polymerizations (LRPs), in particular atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization providing a means for the design and synthesis of new polymeric gene vectors with well-defined compositions, architectures and functionalities is reviewed here. Polymeric gene vectors with different architectures, including homopolymers, block copolymers, graft copolymers, and star-shaped polymers, are conveniently prepared via ATRP and RAFT polymerization. The corresponding synthesis strategies are described in detail. The recent research activities indicate that ATRP and RAFT polymerization have become essential tools for the design and synthesis of advanced, noble and novel gene carriers. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1099 / 1131

页数：33

共 215 条

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