Interplay of foot and mouth disease virus with cell-mediated and humoral immunity of host

被引：16

作者：

Abubakar, Muhammad ^{[1
]}

Manzoor, Shumaila ^{[2
]}

Ahmed, Afshan ^{[2
]}

机构：

[1] Natl Vet Lab, Pk Rd, Islamabad, Pakistan

[2] FAO FMD Project GCP PAK 123 USA, Islamabad, Pakistan

来源：

REVIEWS IN MEDICAL VIROLOGY | 2018年 / 28卷 / 02期

关键词：

cell-mediated immunity; foot and mouth disease; humoral immunity; T cells; RAPIDLY PROTECTS SWINE; ANTIBODY-RESPONSE; INTERFERON EXPRESSION; DENDRITIC CELLS; INFECTED CATTLE; FMDV; RNA; VACCINATION; ACTIVATION; RECEPTOR;

D O I：

10.1002/rmv.1966

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Foot and mouth disease virus (FMDV) causes a communicable disease of cloven hoofed animals, resulting in major economic losses during disease outbreaks. Like other members of the Picornaviridae FMDV has a relatively short infectious cycle; initiation of infection and dissemination, with production of infectious virions occurs in less than a week. The components of innate immunity as well as cell-mediated and humoral immunity play a crucial role in control of FMDV. However, it has been shown in vitro using a mouse model that FMDV has evolved certain mechanisms to counteract host immune responses ensuring its survival and spread. The viral leader proteinase, L pro, deters interferon beta (IFN-) mRNA synthesis, thus, inhibiting host cell translation. Another viral proteinase, 3C pro, disrupts host cell transcription by cleaving histone H3. A transient lymphopenia in swine as a consequence of FMDV infection has also been observed, but the mechanism involved and viral protein(s) associated with this process are not clearly understood. In this review, we have covered the interaction of FMDV with different immune cells including lymphocytes and antigen presenting cells and their consequences.

引用

页数：8

共 76 条

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