Bioinformatics for the synthetic biology of natural products: integrating across the Design-Build-Test cycle

被引：43

作者：

Carbonell, Pablo ^{[1
]}

Currin, Andrew ^{[1
]}

Jervis, Adrian J. ^{[1
]}

Rattray, Nicholas J. W. ^{[1
]}

Swainston, Neil ^{[1
]}

Yan, Cunyu ^{[1
]}

Takano, Eriko ^{[1
]}

Breitling, Rainer ^{[1
]}

机构：

[1] Univ Manchester, Manchester Ctr Fine & Specialty Chem SYNBIOCHEM, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs, England

来源：

NATURAL PRODUCT REPORTS | 2016年 / 33卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

MASS-SPECTROMETRY DATA; MARKUP LANGUAGE SBML; ESCHERICHIA-COLI; SYSTEMS BIOLOGY; RANDOM MUTAGENESIS; METABOLIC NETWORK; GENERATION; PATHWAY; LIBRARIES; ALGORITHM;

D O I：

10.1039/c6np00018e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Progress in synthetic biology is enabled by powerful bioinformatics tools allowing the integration of the design, build and test stages of the biological engineering cycle. In this review we illustrate how this integration can be achieved, with a particular focus on natural products discovery and production. Bioinformatics tools for the DESIGN and BUILD stages include toots for the selection, synthesis, assembly and optimization of parts (enzymes and regulatory elements), devices (pathways) and systems (chassis). TEST tools include those for screening, identification and quantification of metabolites for rapid prototyping. The main advantages and limitations of these toots as well as their interoperability capabilities are highlighted.

引用

页码：925 / 932

页数：8

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