Chronic heart failure modifies respiratory mechanics in rats: a randomized controlled trial

被引：5

作者：

Pacheco, Deise M. ^{[1
,2
]}

Silveira, Viviane D. ^{[1
]}

Thomaz, Alex ^{[1
]}

Nunes, Ramiro B. ^{[1
,3
]}

Elsner, Viviane R. ^{[1
,4
]}

Dal Lago, Pedro ^{[1
,2
,3
]}

机构：

[1] UFCSPA, Lab Fisiol Cardiovasc, Porto Alegre, RS, Brazil

[2] UFCSPA, Programa Posgrad Ciencias Saude, Porto Alegre, RS, Brazil

[3] UFCSPA, Programa Posgrad Ciencias Reabilitacao, Porto Alegre, RS, Brazil

[4] Ctr Univ Metodista IPA, Programa Posgrad Biociencias & Reabilitacao, Porto Alegre, RS, Brazil

来源：

BRAZILIAN JOURNAL OF PHYSICAL THERAPY | 2016年 / 20卷 / 04期

关键词：

heart failure; respiratory mechanics; controlled trial; pulmonary edema; cardiac hypertrophy; rats; ACUTE LUNG INJURY; MYOCARDIAL-INFARCTION; DIASTOLIC PRESSURE; EXERCISE IMPROVES; CHEST-WALL; HYPERRESPONSIVENESS; SYSTEM; VOLUME; SIZE;

D O I：

10.1590/bjpt-rbf.2014.0163

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: To analyze respiratory mechanics and hemodynamic alterations in an experimental model of chronic heart failure (CHF) following myocardial infarction. Method: Twenty-seven male adult Wistar rats were randomized to CHF group (n=12) or Sham group (n=15). Ten weeks after coronary ligation or sham surgery, the animals were anesthetized and submitted to respiratory mechanics and hemodynamic measurements. Pulmonary edema as well as cardiac remodeling were measured. Results: The CHF rats showed pulmonary edema 26% higher than the Sham group. The respiratory system compliance (Crs) and the total lung capacity (TLC) were lower (40% and 27%, respectively) in the CHF rats when compared to the Sham group (P<0.01). There was also an increase in tissue resistance (Gti) and elastance (Hti) ( 28% and 45%, respectively) in the CHF group. Moreover, left ventricular end-diastolic pressure was higher (32 mmHg vs 4 mmHg, P<0.01), while the left ventricular systolic pressure was lower (118 mmHg vs 130 mmHg, P=0.02) in the CHF group when compared to the control. Pearson's correlation coefficient showed a negative association between pulmonary edema and Crs (r=-0.70, P=0.0001) and between pulmonary edema and TLC (r=-0.67, P=0.0034). Pulmonary edema correlated positively with Gti (r=0.68, P=0.001) and Hti (r=0.68, P=0.001). Finally, there was a strong positive relationship between pulmonary edema and heart weight (r=0.80, P=0.001). Conclusion: Rats with CHF present important changes in hemodynamic and respiratory mechanics, which may be associated with alterations in cardiopulmonary interactions.

引用

页码：320 / 327

页数：8