Concise Total Synthesis and Stereochemical Revision of all (-)-Trigonoliimines

被引：113

作者：

Han, Sunkyu ^{[1
]}

Movassaghi, Mohammad ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 28期

关键词：

STEREOCONTROLLED TOTAL-SYNTHESIS; ASYMMETRIC EPOXIDATION; ENANTIOSELECTIVE EPOXIDATION; OXIDATIVE REARRANGEMENT; ROOM-TEMPERATURE; ALKALOIDS; COMPLEXES; OLEFINS; BIOSYNTHESIS; DERIVATIVES;

D O I：

10.1021/ja204597k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The concise and enantioselective total syntheses of (-)-trigonoliimines A, B, and C are described. Our unified strategy to all three natural products is based on asymmetric oxidation and reorganization of a single bistryptamine, a sequence of transformations with possible biogenetic relevance. We revise the absolute stereo chemistry of (-)-trigonoliimines A, B, and C.

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页码：10768 / 10771

页数：4

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