Can we switch production of toxic Aβ oligomers to neuroprotective Aβ monomers to allow synapse regeneration?

被引：1

作者：

Bate, Clive ^{[1
]}

机构：

[1] Royal Vet Coll, Dept Pathol & Pathogen Biol, Hawkshead Lane, N Mymms, Herts, England

来源：

NEURAL REGENERATION RESEARCH | 2017年 / 12卷 / 09期

关键词：

ALZHEIMERS-DISEASE; PROTEIN;

D O I：

10.4103/1673-5374.215252

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：1437 / 1438

页数：2

共 9 条

[1] Enhanced neuronal degradation of amyloid-β oligomers allows synapse regeneration [J].

Bate, Clive .

NEURAL REGENERATION RESEARCH, 2015, 10 (05) :700-701

[2] Natural oligomers of the amyloid-protein specifically disrupt cognitive function [J].

Cleary, JP ;

Walsh, DM ;

Hofmeister, JJ ;

Shankar, GM ;

Kuskowski, MA ;

Selkoe, DJ ;

Ashe, KH .

NATURE NEUROSCIENCE, 2005, 8 (01) :79-84

[3] β-Amyloid Monomers Are Neuroprotective [J].

Giuffrida, Maria Laura ;

Caraci, Filippo ;

Pignataro, Bruno ;

Cataldo, Sebastiano ;

De Bona, Paolo ;

Bruno, Valeria ;

Molinaro, Gemma ;

Pappalardo, Giuseppe ;

Messina, Angela ;

Palmigiano, Angelo ;

Garozzo, Domenico ;

Nicoletti, Ferdinando ;

Rizzarelli, Enrico ;

Copani, Agata .

JOURNAL OF NEUROSCIENCE, 2009, 29 (34) :10582-10587

[4] ALZHEIMERS-DISEASE - THE AMYLOID CASCADE HYPOTHESIS [J].

HARDY, JA ;

HIGGINS, GA .

SCIENCE, 1992, 256 (5054) :184-185

[5] Sialylated glycosylphosphatidylinositols suppress the production of toxic amyloid-β oligomers [J].

Nolan, William ;

McHale-Owen, Harriet ;

Bate, Clive .

BIOCHEMICAL JOURNAL, 2017, 474 :3045-3058

[6] The antibody aducanumab reduces Aβ plaques in Alzheimer's disease [J].

Sevigny, Jeff ;

Chiao, Ping ;

Bussiere, Thierry ;

Weinreb, Paul H. ;

Williams, Leslie ;

Maier, Marcel ;

Dunstan, Robert ;

Salloway, Stephen ;

Chen, Tianle ;

Ling, Yan ;

O'Gorman, John ;

Qian, Fang ;

Arastu, Mahin ;

Li, Mingwei ;

Chollate, Sowmya ;

Brennan, Melanie S. ;

Quintero-Monzon, Omar ;

Scannevin, Robert H. ;

Arnold, H. Moore ;

Engber, Thomas ;

Rhodes, Kenneth ;

Ferrero, James ;

Hang, Yaming ;

Mikulskis, Alvydas ;

Grimm, Jan ;

Hock, Christoph ;

Nitsch, Roger M. ;

Sandrock, Alfred .

NATURE, 2016, 537 (7618) :50-56

[7]

Suzuki KGN, 2012, NAT CHEM BIOL, V8, P774, DOI [10.1038/NCHEMBIO.1028, 10.1038/nchembio.1028]

[8] Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease [J].

Sze, CI ;

Troncoso, JC ;

Kawas, C ;

Mouton, P ;

Price, DL ;

Martin, LJ .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1997, 56 (08) :933-944

[9] Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate [J].

Yang, Ting ;

Li, Shaomin ;

Xu, Huixin ;

Walsh, Dominic M. ;

Selkoe, Dennis J. .

JOURNAL OF NEUROSCIENCE, 2017, 37 (01) :152-163

← 1 →