Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

被引：22
作者：
Han, Limin [1 ,2 ]
Fu, Qiang [3 ,4 ]
Deng, Chuan [5 ]
Luo, Li [6 ]
Xiang, Tengxiao [2 ]
Zhao, Hailong [1 ]
机构：
[1] Zunyi Med Univ, Dept Pathophysiol, 6 Xuefu West Rd, Zunyi 563000, Guizhou, Peoples R China
[2] Peoples Hosp Changshou Chongqing, Dept Endocrinol, Chongqing, Peoples R China
[3] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Organ Transplantat Ctr, Sch Med, Chengdu, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu, Peoples R China
[5] Peoples Hosp Changshou Chongqing, Dept Neurol, Chongqing, Peoples R China
[6] Zunyi Med Univ, Dept Forens Med, Zunyi, Guizhou, Peoples R China
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2022年 / 95卷 / 01期
基金：
中国国家自然科学基金;
关键词：
adaptive immunity; autoimmune diseases; flavonoids; gut microbiota; immunocyte; innate immunity; tumour microenvironment; GUT MICROBIOTA COMPOSITION; DENDRITIC-CELL MATURATION; PROSTATE-CANCER RISK; REGULATORY T-CELLS; ANTIINFLAMMATORY ACTIVITY; AIRWAY INFLAMMATION; DIETARY FLAVONOIDS; BREAST-CANCER; MURINE MODEL; IN-VITRO;
D O I：
10.1111/sji.13106
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immune system plays an indispensable role in maintaining human health against the invasion of foreign materials, microorgainisms and pathogens. The autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation, as well as tumour, and others. In recent years, flavonoids are widely recognized as potentially natural polyphenol compounds for the treatment of multiple diseases, given their immunomodulatory activity, antioxidant and antineoplastic activities. However, the exact mechanisms of flavonoids on the immune system and inhibiting tumour remains unclear. This review article provides an overview of the impact and mechanism of flavonoids on innate and adaptive immune system through the analysis of various immune cells. Meanwhile, we also explain the probable therapeutic mechanism of flavonoids on tumour and other chronic diseases. Overall, this review may provide a certain theoretical direction and theoretical basis for the application of flavonoids in the treatment of immune-related disorders and tumour.
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页数：19
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