Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

被引：22
作者：
Han, Limin [1 ,2 ]
Fu, Qiang [3 ,4 ]
Deng, Chuan [5 ]
Luo, Li [6 ]
Xiang, Tengxiao [2 ]
Zhao, Hailong [1 ]
机构：
[1] Zunyi Med Univ, Dept Pathophysiol, 6 Xuefu West Rd, Zunyi 563000, Guizhou, Peoples R China
[2] Peoples Hosp Changshou Chongqing, Dept Endocrinol, Chongqing, Peoples R China
[3] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Organ Transplantat Ctr, Sch Med, Chengdu, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu, Peoples R China
[5] Peoples Hosp Changshou Chongqing, Dept Neurol, Chongqing, Peoples R China
[6] Zunyi Med Univ, Dept Forens Med, Zunyi, Guizhou, Peoples R China
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2022年 / 95卷 / 01期
基金：
中国国家自然科学基金;
关键词：
adaptive immunity; autoimmune diseases; flavonoids; gut microbiota; immunocyte; innate immunity; tumour microenvironment; GUT MICROBIOTA COMPOSITION; DENDRITIC-CELL MATURATION; PROSTATE-CANCER RISK; REGULATORY T-CELLS; ANTIINFLAMMATORY ACTIVITY; AIRWAY INFLAMMATION; DIETARY FLAVONOIDS; BREAST-CANCER; MURINE MODEL; IN-VITRO;
D O I：
10.1111/sji.13106
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immune system plays an indispensable role in maintaining human health against the invasion of foreign materials, microorgainisms and pathogens. The autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation, as well as tumour, and others. In recent years, flavonoids are widely recognized as potentially natural polyphenol compounds for the treatment of multiple diseases, given their immunomodulatory activity, antioxidant and antineoplastic activities. However, the exact mechanisms of flavonoids on the immune system and inhibiting tumour remains unclear. This review article provides an overview of the impact and mechanism of flavonoids on innate and adaptive immune system through the analysis of various immune cells. Meanwhile, we also explain the probable therapeutic mechanism of flavonoids on tumour and other chronic diseases. Overall, this review may provide a certain theoretical direction and theoretical basis for the application of flavonoids in the treatment of immune-related disorders and tumour.
引用
收藏
页数：19
相关论文
共 213 条
[1]   Naringenin mitigates autoimmune features in lupus-prone mice by modulation of T-cell subsets and cytokines profile [J].
Abrego-Peredo, Amayrani ;
Romero-Ramirez, Hector ;
Espinosa, Enrique ;
Lopez-Herrera, Gabriela ;
Garcia-Garcia, Fabio ;
Flores-Munoz, Monica ;
Sandoval-Montes, Claudia ;
Carlos Rodriguez-Alba, Juan .
PLOS ONE, 2020, 15 (05)
[2]   Dab2, a negative regulator of DC immunogenicity, is an attractive molecular target for DC-based immunotherapy [J].
Ahmed, Md. Selim ;
Byeon, Se Eun ;
Jeong, Yideul ;
Miah, Mohammad Alam ;
Salahuddin, Md ;
Lee, Yoon ;
Park, Sung-Soo ;
Bae, Yong-Soo .
ONCOIMMUNOLOGY, 2015, 4 (01) :984550
[3]   Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-κB [J].
Ahn, SC ;
Kim, GY ;
Kim, JH ;
Baik, SW ;
Han, MK ;
Lee, HJ ;
Moon, DO ;
Lee, CM ;
Kang, JH ;
Kim, BH ;
Oh, YH ;
Park, YM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 313 (01) :148-155
[4]   Protective role of quercetin against hematotoxic and immunotoxic effects of furan in rats [J].
Alam, Rasha T. ;
Abu Zeid, Ehsan H. ;
Imam, Tamer S. .
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2017, 24 (04) :3780-3789
[5]   In Vitro Effects of Some Flavones on Human Pyruvate Kinase Isoenzyme M2 [J].
Aslan, Erdem ;
Adem, Sevki .
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2015, 29 (03) :109-113
[6]   Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].
Atarashi, Koji ;
Tanoue, Takeshi ;
Shima, Tatsuichiro ;
Imaoka, Akemi ;
Kuwahara, Tomomi ;
Momose, Yoshika ;
Cheng, Genhong ;
Yamasaki, Sho ;
Saito, Takashi ;
Ohba, Yusuke ;
Taniguchi, Tadatsugu ;
Takeda, Kiyoshi ;
Hori, Shohei ;
Ivanov, Ivaylo I. ;
Umesaki, Yoshinori ;
Itoh, Kikuji ;
Honda, Kenya .
SCIENCE, 2011, 331 (6015) :337-341
[7]   Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor [J].
Ayoub, Iriny M. ;
Korinek, Michal ;
Hwang, Tsong-Long ;
Chen, Bing-Hung ;
Chang, Fang-Rong ;
El-Shazly, Mohamed ;
Singab, Abdel Nasser B. .
JOURNAL OF NATURAL PRODUCTS, 2018, 81 (02) :243-253
[8]   Quercetin Enhances Susceptibility to NK Cell-mediated Lysis of Tumor Cells Through Induction of NKG2D Ligands and Suppression of HSP70 [J].
Bae, Jae-Ho ;
Kim, Joo-Young ;
Kim, Mi-Ju ;
Chang, Sung-Ho ;
Park, You-Soo ;
Son, Cheol-Hun ;
Park, Soo-Jung ;
Chung, Joo-Seop ;
Lee, Eun-Yup ;
Kim, Sun-Hee ;
Kang, Chi-Dug .
JOURNAL OF IMMUNOTHERAPY, 2010, 33 (04) :391-401
[9]   Modulation of regulatory T cells by natural products in cancer [J].
Bahrami, Afsane ;
Fereidouni, Mohammad ;
Pirro, Matteo ;
Bianconi, Vanessa ;
Sahebkar, Amirhossein .
CANCER LETTERS, 2019, 459 :72-85
[10]   COVID-19 infection in kidney transplant recipients [J].
Banerjee, Debasish ;
Popoola, Joyce ;
Shah, Sapna ;
Ster, Irina Chis ;
Quan, Virginia ;
Phanish, Mysore .
KIDNEY INTERNATIONAL, 2020, 97 (06) :1076-1082
12345678910