Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations

被引:27
作者
Wu, Qinghua [1 ]
Wu, Wenda [2 ]
Franca, Tanos C. C. [3 ,4 ]
Jacevic, Vesna [5 ,6 ,7 ]
Wang, Xu [8 ,9 ]
Kuca, Kamil [7 ]
机构
[1] Yangtze Univ, Coll Life Sci, Jinzhou 434025, Peoples R China
[2] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China
[3] Mil Inst Engn, Lab Mol Modeling Appl Chem & Biol Def, Praca Gen Tiburcio 80, BR-22290270 Rio De Janeiro, RJ, Brazil
[4] Univ Hradec Kralove, Ctr Basic & Appl Res, Fac Informat & Management, Rokitanskeho 62, Hradec Kralove 50003, Czech Republic
[5] Mil Med Acad, Dept Expt Toxicol & Pharmacol, Natl Poison Control Ctr, 11 Crnotravska St, Belgrade 11000, Serbia
[6] Univ Def Belgrade, Fac Med, Mil Med Acad, 1 Pavla Jurisica Sturma St, Belgrade 11000, Serbia
[7] Univ Hradec Kralove, Dept Chem, Fac Sci, Hradec Kralove 50003, Czech Republic
[8] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Peoples R China
[9] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
immune evasion; trichothecenes; T-2; toxin; immunotoxicity; negative immune regulations; T-2; TOXIN; DEOXYNIVALENOL; PATHWAYS;
D O I
10.3390/ijms19113307
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation". This news has increased the attention on immunotoxicity and immune evasion mechanisms, which are once again hot research topics. Actually, increasing lines of evidence show that trichothecene mycotoxins have a strong immunosuppressive effect. These mycotoxins suppress the host immunity and make them more sensitive to the infection of pathogens, including bacteria and viruses. However, the underlying mechanism(s) in this context is still poorly understood. Interestingly, recent work showed that an immune evasion mechanism might be involved in trichothecene immunotoxicity. In this work, we discuss the potential immune evasion mechanism in trichothecene immunotoxicity. More importantly, under these circumstances, we are pleased to compile a Special Issue entitled "Biochemistry, Molecular Biology, and Toxicology of Natural and Synthetic Toxins" for the International Journal of Molecular Sciences (IJMS). Researchers are encouraged to share their latest interesting findings with the readers of IJMS.
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页数:4
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