Inhibition of WEE1 is effective in TP53 and RAS mutant metastatic colorectal cancer (mCRC): A randomised phase II trial (FOCUS4-C) comparing adavosertib (AZD1775) with active monitoring

被引：1

作者：

Seligmann, J. ^{[1
]}

Fisher, D. J. ^{[2
]}

Brown, L. C. ^{[2
]}

Adams, R. ^{[3
]}

Graham, J. ^{[4
]}

Quirke, P. ^{[5
]}

Richman, S. ^{[5
]}

Butler, R. ^{[3
]}

Domingo, E. ^{[6
]}

Blake, A. ^{[6
]}

Braun, M. ^{[7
]}

Collinson, F. ^{[1
]}

Jones, R. ^{[3
]}

Brown, E. ^{[8
]}

De Winton, E. ^{[9
]}

Humphies, T. ^{[6
]}

Kaplan, R. ^{[2
]}

Wilson, R. ^{[4
]}

Seymour, M. ^{[1
]}

Maughan, T. ^{[10
]}

机构：

[1] Leeds Teaching Hosp NHS Trust Leeds, St Jamess Univ Hosp, Oncol Dept, Leeds, W Yorkshire, England

[2] UCL, MRC Clin Trials Unit, London, England

[3] Velindre Canc Ctr, Oncol, Cardiff, Wales

[4] Beatson Canc Ctr, Med Oncol, Glasgow, Lanark, Scotland

[5] Leeds Teaching Hosp NHS Trust, St Jamess Univ Hosp, Pathol Dept, Leeds, W Yorkshire, England

[6] Univ Oxford, MRC Oxford Inst Radiat Oncol, Oxford, England

[7] Christie Hosp, Med Oncol, Manchester, Lancs, England

[8] Western Gen Hosp, Med Oncol, Edinburgh, Midlothian, Scotland

[9] Royal United Hosp, Med Oncol, Bath, Avon, England

[10] Oxford Inst Radiat Oncol, Oncol, Oxford, England

来源：

ANNALS OF ONCOLOGY | 2021年 / 32卷

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.annonc.2021.08.904

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

382O

引用

页码：S530 / S530

页数：1