Genistein: Its role in metabolic diseases and cancer

被引：207

作者：

Mukund, Vidya ^{[1
]}

Mukund, Dhruv ^{[2
]}

Sharma, Vinay ^{[1
]}

Mannarapu, Mastan ^{[3
]}

Alam, Afroz ^{[1
]}

机构：

[1] Banasthali Univ, Dept Biosci & Biotechnol, Banasthali 304022, Raj, India

[2] Pace Jr Coll, Bombay 400028, Maharashtra, India

[3] Dravidian Univ, Dept Biotechnol, Kuppam 517426, AP, India

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2017年 / 119卷

关键词：

Genistein; Metabolic diseases; Insulin; Adipogenesis; Cancer; NF-KAPPA-B; MATRIX-METALLOPROTEINASE TYPE-2; TYROSINE KINASE INHIBITOR; CORONARY-HEART-DISEASE; FOCAL ADHESION KINASE; BREAST-CANCER; GROWTH-FACTOR; SOY ISOFLAVONES; CELL INVASION; IN-VITRO;

D O I：

10.1016/j.critrevonc.2017.09.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genistein is an isoflavone present in soy and is known to have multiple molecular effects, such as the inhibition of inflammation, promotion of apoptosis, and modulation of steroidal hormone receptors and metabolic pathways. Since these molecular effects impact carcinogenesis, cancer propagation, obesity, osteoporosis, and metabolic syndromes, genistein plays an important role in preventing and treating common disorders. The role of genistein has not been adequately evaluated in all these clinical settings. This review summarizes some of the known molecular effects of genistein and its potential role in health maintenance and treatment.

引用

页码：13 / 22

页数：10

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