Iron and Parkinson's disease

被引:0
作者
Di Lorenzo, Francesco [1 ]
机构
[1] Ambulatorio Privato Sci Med, I-70010 Bari, Italy
关键词
Parkinson's disease; iron; neurodegeneration; oxidative stress; METAL TRANSPORTER 1; SUBSTANTIA-NIGRA; ALPHA-SYNUCLEIN; DOPAMINE; DESFERRIOXAMINE; ALUMINUM; NEURODEGENERATION; PATHOGENESIS; OSTEOMALACIA; CHELATION;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this case presentation, a man with a diagnosis of Parkinson's disease was treated with Chelation Therapy against iron without iron serum level correlation. The patient, who suffered from motor and non-motor symptoms of the disease, showed an improved condition after the Therapy. This clinical test was evaluated with UPDRS III score. The rationale and the limits of the Therapy are discussed. This case suggests that iron-dependent oxidative stress could represent a promising therapy for this dramatic disease; the necessity to deeply study the iron metabolism in neuro-degeneration appears really significant.
引用
收藏
页码:24 / 27
页数:4
相关论文
共 30 条
[1]   Dopamine complexes of iron in the etiology and pathogenesis of Parkinson's disease [J].
Arreguin, Shelly ;
Nelson, Paul ;
Padway, Shelby ;
Shirazi, Matthew ;
Pierpont, Cortlandt .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2009, 103 (01) :87-93
[2]   Studies of aminochrome toxicity in a mouse derived neuronal cell line: is this toxicity mediated via glutamate transmission? [J].
Arriagada, C ;
Dagnino-Subiabre, A ;
Caviedes, P ;
Armero, JM ;
Caviedes, R ;
Segura-Aguilar, J .
AMINO ACIDS, 2000, 18 (04) :363-373
[3]  
BROWN DJ, 1982, LANCET, V2, P343
[4]  
CIANCIONI C, 1984, T AM SOC ART INT ORG, V30, P479
[5]   The doparnine receptor agonist lisuride attenuates iron-mediated dopaminergic neurodegeneration [J].
Double, KL ;
Halliday, GM ;
Henderson, J ;
Griffiths, FM ;
Heinemann, T ;
Riederer, P ;
Gerlach, M .
EXPERIMENTAL NEUROLOGY, 2003, 184 (01) :530-535
[6]   Magnesium inhibits spontaneous and iron-induced aggregation of α-synuclein [J].
Golts, N ;
Snyder, H ;
Frasier, M ;
Theisler, C ;
Choi, P ;
Wolozin, B .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (18) :16116-16123
[7]   The relevance of iron in the pathogenesis of Parkinson's disease [J].
Götz, ME ;
Double, K ;
Gerlach, M ;
Youdim, MBH ;
Riederer, P .
REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS, 2004, 1012 :193-208
[8]   Hemochromatosis and vitamin C [J].
Herbert, V .
ANNALS OF INTERNAL MEDICINE, 1999, 131 (06) :475-476
[9]   Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: Implications for Parkinson's disease [J].
Kaur, Deepinder ;
Lee, Donna ;
Ragapolan, Subramanian ;
Andersen, Julie K. .
FREE RADICAL BIOLOGY AND MEDICINE, 2009, 46 (05) :593-598
[10]  
Lienert W, 2012, METAL IONS NEUROLOGI, V2, P12