New perspectives in the treatment of adult medulloblastoma in the era of molecular oncology

被引：29
作者：
Brandes, Alba A. [1 ]
Bartlotti, Marco [1 ]
Marucci, Gianluca [2 ]
Ghimenton, Claudio [3 ]
Agati, Raffaele [4 ]
Fioravanti, Antonio [5 ]
Mascarin, Maurizio [6 ]
Volpin, Lorenzo [7 ]
Ammannati, Franco [8 ]
Masotto, Barbara [9 ]
Gardiman, Marina Paola [10 ]
De Biase, Dario [11 ]
Tallini, Giovanni [11 ]
Crisi, Girolamo [12 ]
Bartolini, Stefania
Franceschi, Enrico [1 ]
机构：
[1] Bellaria Maggiore Hosp, Azienda USL IRCCS Inst Neurol Sci, Dept Med Oncol, I-40139 Bologna, Italy
[2] Univ Bologna, Sect Pathol, M Malpighi Bellaria Hosp, Dept Biomed & NeuroMotor Sci DiBiNeM, Bologna, Italy
[3] Verona Hosp, Dept Pathol, Verona, Italy
[4] Bellaria Maggiore Hosp, Azienda USL IRCCS Inst Neurol Sci, Dept Neuroradiol, Bologna, Italy
[5] Bellaria Hosp, IRCCS Inst Neurol Sci, Dept Neurosurg, Azienda USL, Bologna, Italy
[6] CRO, Dept Radiotherapy Unit, Aviano, Italy
[7] San Bortolo Hosp, Dept Neurosci & Neurosurg, Vicenza, Italy
[8] Careggi Univ Hosp, Dept Neurosurg 1, Florence, Italy
[9] Univ Verona, Dept Neurosci, Neurosurg Sect, I-37100 Verona, Italy
[10] Univ Hosp, Dept Med DIMED, Surg Pathol & Cytopathol Unit, Padua, Italy
[11] Univ Bologna, Bellaria Hosp, Anat Pathol Unit, Dept Med DIMES, Bologna, Italy
[12] Parma Univ Hosp, Dept Neuroradiol, Parma, Italy
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2015年 / 94卷 / 03期
关键词：
Medulloblastoma; Adults; Treatment; SHH; WNT; HIGH-DOSE CHEMOTHERAPY; STEM-CELL RESCUE; CRANIOSPINAL RADIATION-THERAPY; PROSPECTIVE RANDOMIZED-TRIAL; HIGH-RISK MEDULLOBLASTOMA; NONMETASTATIC MEDULLOBLASTOMA; ADJUVANT CHEMOTHERAPY; PROGNOSTIC-FACTORS; BRAIN; RECURRENT;
D O I：
10.1016/j.critrevonc.2014.12.016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Medulloblastoma is the most common central nervous system tumor in children, while it is extremely rare in adults. Multimodal treatment involving surgery, radiotherapy and chemotherapy can improve the prognosis of this disease, and recent advances in molecular biology have allowed the identification of molecular subgroups (WNT, SHH, Groups 3 and 4), each of which have different cytogenetic, mutational and gene expression signatures, demographics, histology and prognosis. The present review focuses on the state of the art for adult medulloblastoma treatment and on novel molecular advances and their future implications in the treatment of this disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：348 / 359
页数：12
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