Risk Stratification Using the CHA2DS2-VASc Score in Takotsubo Syndrome: Data From the Takotsubo Italian Network

被引：26

作者：

Parodi, Guido ^{[1
,2
]}

Scudiero, Fernando ^{[1
]}

Citro, Rodolfo ^{[3
]}

Silverio, Angelo ^{[3
]}

Bellandi, Benedetta ^{[1
]}

Zito, Concetta ^{[4
]}

Antonini-Canterin, Francesco ^{[5
]}

Rigo, Fausto ^{[6
]}

Zocchi, Chiara ^{[1
]}

Bossone, Eduardo ^{[3
]}

Salerno-Uriarte, Jorge ^{[7
]}

Piscione, Federico ^{[3
]}

Di Mario, Carlo ^{[1
]}

机构：

[1] Careggi Univ Hosp, Cardiovasc & Thorac Dept, Largo Brambilla 3, Florence, Italy

[2] Sassari Univ Hosp, Clin & Intervent Cardiol, Sassari, Italy

[3] Univ Hosp San Giovanni di Dio & Ruggi dAragona, Salerno, Italy

[4] Univ Messina, Dept Clin & Expt Med, Messina, Italy

[5] S Maria Angeli Hosp, Div Cardiol, Pordenone, Italy

[6] DellAngelo Hosp, Dept Cardiol, Venice, Italy

[7] Univ Insubria, Dept Cardiol, Osped Circolo & Fond Macchi, Varese, Italy

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2017年 / 6卷 / 09期

关键词：

anticoagulant; cardiovascular events; CHA(2)DS(2)-VASc score; stroke; Takotsubo; Takotsubo cardiomyopathy; Takotsubo syndrome; ATRIAL-FIBRILLATION; CHADS(2) SCORE; STROKE RISK; OUTCOMES;

D O I：

10.1161/JAHA.117.006065

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-The CHA(2)DS(2)-VASc score predicts stroke in patients with atrial fibrillation and has been reported to have a prognostic role even in acute coronary syndrome patients. The Takotsubo syndrome is a condition that mimics acute coronary syndrome and may present several complications including stroke. We sought to assess the ability of CHA2DS2-VASc score to predict adverse events in Takotsubo syndrome patients. Methods and Results-Overall, 371 Takotsubo syndrome patients were enrolled in a prospective registry. Patients were divided into 3 groups according to the CHA2DS2-VASc score: Group A (<= 1), B (2-3), and C (>= 4). The median CHA2DS2-VASc score was 3 (interquartile range: 2-4). Overall, 9%, 42%, and 49% were included in Group A, B, and C, respectively. Follow-up length was 26 +/- 20 months. The mortality rate was 6%, 7%, and 17% in Group A, B, and C, respectively (P=0.011). The stroke rate was 3% and not different among the 3 groups. Estimated major adverse cardiac and cerebrovascular events (the composite of death, myocardial infarction, and stroke) rates in the 3 groups were 6%, 9%, and 17% in Group A, B, and C, respectively (P=0.033). The CHA2DS2-VASc score resulted as a predictor of major adverse cardiac and cerebrovascular events (odds ratio 2.1, 95% confidence interval, 1.2-3.6; P= 0.01) and all-cause mortality (odds ratio 1.5, 95% confidence interval, 1.2-1.9; P= 0.001). Conclusions-In Takotsubo syndrome, the CHA2DS2-VASc score allows prediction of cardiovascular events and mortality at longterm follow-up.

引用

页数：6

共 14 条

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