Protective Immunity to Chlamydial Genital Infection: Evidence from Animal Studies

被引：65

作者：

Rank, Roger G. ^{[1
]}

Whittum-Hudson, Judith A. ^{[2
]}

机构：

[1] Arkansas Childrens Hosp, Res Inst, Little Rock, AR 72202 USA

[2] Wayne State Univ, Sch Med, Detroit, MI USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷

关键词：

PIG INCLUSION CONJUNCTIVITIS; FEMALE GUINEA-PIGS; MOUSE PNEUMONITIS BIOVAR; CD8(+) T-CELLS; TRACT INFECTION; TRACHOMATIS INFECTION; INTRAVAGINAL INFECTION; ACQUIRED-IMMUNITY; OCULAR INFECTION; SERUM ANTIBODY;

D O I：

10.1086/652399

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In all animal models for chlamydial infection, there is strong evidence for immunity to reinfection; however, immunity is only complete (ie, preventing infection) in the short term. In the long term, animals are only partially immune (ie, they can be reinfected, but infections are usually abbreviated and less intense than the primary infection). This review will target the mechanisms responsible for long-term versus short-term immunity and explore the roles of various components of the host response in immunity to chlamydial genital infection.

引用

页码：S168 / S177

页数：10

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